The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration

Research output: Contribution to journalArticle (Academic Journal)peer-review

227 Citations (Scopus)

Abstract

The classical concept of hypothalamus-pituitary-adrenal (HPA) homeostasis comprises a feedback system within which circulating levels of glucocorticoid hormones maintain the brain and body in an optimal steady state. However, studies involving new techniques for investigating the real-time dynamics of both glucocorticoid hormones and glucocorticoid receptor function paint a different picture - namely, of continuous dynamic equilibration throughout this neuroendocrine system. This dynamic state is dictated by feedforward and feedback regulatory loops and by stochastic interactions at the level of DNA binding. We propose that this continuous oscillatory activity is crucial for optimal responsiveness of glucocorticoid-sensitive neural processes.
Translated title of the contributionThe crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration
Original languageEnglish
Pages (from-to)710 - 718
Number of pages9
JournalNature Reviews Neuroscience
Volume11
Publication statusPublished - Oct 2010

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