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The de novo design of α-helical peptides for supramolecular self-assembly

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The de novo design of α-helical peptides for supramolecular self-assembly. / Beesley, Joe; Woolfson, Dek.

In: Current Opinions in Biotechnology, Vol. 58, 01.08.2019, p. 175-182.

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Beesley, Joe ; Woolfson, Dek. / The de novo design of α-helical peptides for supramolecular self-assembly. In: Current Opinions in Biotechnology. 2019 ; Vol. 58. pp. 175-182.

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@article{f8347cf3b60644fbb9a79c8a50f0695d,
title = "The de novo design of α-helical peptides for supramolecular self-assembly",
abstract = "One approach to designing de novo proteinaceous assemblies and materials is to develop simple, standardised building blocks and then to combine these symmetrically to construct more-complex higher-order structures. This has been done extensively using β-structured peptides to produce peptide fibres and hydrogels. Here, we focus on building with de novo α-helical peptides. Because of their self-contained, well-defined structures and clear sequence-to-structure relationships, α helices are highly programmable making them robust building blocks for biomolecular construction. The progress made with this approach over the past two decades is astonishing and has led to a variety of de novo assemblies, including discrete nanoscale objects, and fibrous, nanotube, sheet and colloidal materials. This body of work provides an exceptionally strong foundation for advancing the field beyond in vitro design and into in vivo applications including what we call protein design in cells.",
keywords = "synthetic biology",
author = "Joe Beesley and Dek Woolfson",
year = "2019",
month = "8",
day = "1",
doi = "10.1016/j.copbio.2019.03.017",
language = "English",
volume = "58",
pages = "175--182",
journal = "Current Opinions in Biotechnology",
issn = "0958-1669",
publisher = "Elsevier Limited",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - The de novo design of α-helical peptides for supramolecular self-assembly

AU - Beesley, Joe

AU - Woolfson, Dek

PY - 2019/8/1

Y1 - 2019/8/1

N2 - One approach to designing de novo proteinaceous assemblies and materials is to develop simple, standardised building blocks and then to combine these symmetrically to construct more-complex higher-order structures. This has been done extensively using β-structured peptides to produce peptide fibres and hydrogels. Here, we focus on building with de novo α-helical peptides. Because of their self-contained, well-defined structures and clear sequence-to-structure relationships, α helices are highly programmable making them robust building blocks for biomolecular construction. The progress made with this approach over the past two decades is astonishing and has led to a variety of de novo assemblies, including discrete nanoscale objects, and fibrous, nanotube, sheet and colloidal materials. This body of work provides an exceptionally strong foundation for advancing the field beyond in vitro design and into in vivo applications including what we call protein design in cells.

AB - One approach to designing de novo proteinaceous assemblies and materials is to develop simple, standardised building blocks and then to combine these symmetrically to construct more-complex higher-order structures. This has been done extensively using β-structured peptides to produce peptide fibres and hydrogels. Here, we focus on building with de novo α-helical peptides. Because of their self-contained, well-defined structures and clear sequence-to-structure relationships, α helices are highly programmable making them robust building blocks for biomolecular construction. The progress made with this approach over the past two decades is astonishing and has led to a variety of de novo assemblies, including discrete nanoscale objects, and fibrous, nanotube, sheet and colloidal materials. This body of work provides an exceptionally strong foundation for advancing the field beyond in vitro design and into in vivo applications including what we call protein design in cells.

KW - synthetic biology

UR - http://www.scopus.com/inward/record.url?scp=85064763584&partnerID=8YFLogxK

U2 - 10.1016/j.copbio.2019.03.017

DO - 10.1016/j.copbio.2019.03.017

M3 - Review article

VL - 58

SP - 175

EP - 182

JO - Current Opinions in Biotechnology

JF - Current Opinions in Biotechnology

SN - 0958-1669

ER -