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The development and validation of a human screening model of tobacco abstinence

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The development and validation of a human screening model of tobacco abstinence. / Grabski, Meryem; Curran, H Valerie; Nutt, David J; Husbands, Stephen M; Ferguson, Stuart G; Munafò, Marcus R.

In: Drug and Alcohol Dependence, Vol. 206, 01.01.2020, p. 107720.

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Harvard

Grabski, M, Curran, HV, Nutt, DJ, Husbands, SM, Ferguson, SG & Munafò, MR 2020, 'The development and validation of a human screening model of tobacco abstinence', Drug and Alcohol Dependence, vol. 206, pp. 107720. https://doi.org/10.1016/j.drugalcdep.2019.107720

APA

Grabski, M., Curran, H. V., Nutt, D. J., Husbands, S. M., Ferguson, S. G., & Munafò, M. R. (2020). The development and validation of a human screening model of tobacco abstinence. Drug and Alcohol Dependence, 206, 107720. https://doi.org/10.1016/j.drugalcdep.2019.107720

Vancouver

Grabski M, Curran HV, Nutt DJ, Husbands SM, Ferguson SG, Munafò MR. The development and validation of a human screening model of tobacco abstinence. Drug and Alcohol Dependence. 2020 Jan 1;206:107720. https://doi.org/10.1016/j.drugalcdep.2019.107720

Author

Grabski, Meryem ; Curran, H Valerie ; Nutt, David J ; Husbands, Stephen M ; Ferguson, Stuart G ; Munafò, Marcus R. / The development and validation of a human screening model of tobacco abstinence. In: Drug and Alcohol Dependence. 2020 ; Vol. 206. pp. 107720.

Bibtex

@article{55000ce21d864f9faf44053079cadf10,
title = "The development and validation of a human screening model of tobacco abstinence",
abstract = "INTRODUCTION: Given the low efficacy of smoking cessation methods, an experimental medicine model indicating smoking abstinence would be of great benefit to the development of new treatments. Hence the sensitivity of cognitive tasks and ambulatory craving measures to smoking abstinence were investigated.METHODS: Cognitive tasks and ambulatory ratings of craving were assessed for sensitivity to acute abstinence (experiment 1), and nicotine replacement therapy administration (NRT) (experiment 2).RESULTS: In experiment 1 go/no-go performance was improved (Mean Difference [MD] -0.99, 95{\%} CI: -1.90 to -0.08) and craving was lower (Regression Coefficient [RC] -33.39, 95{\%} CI: -39.96 to -26.82) in satiated compared with abstinent smokers. There was no clear evidence that N-back (MD 0.64, 95{\%} CI: -0.42 to 2.51), delay discounting (MD 0.01, 95{\%} CI: 0.001 to 0.005) or dot probe performance (MD 0.61, 95{\%} CI: -0.87 to 1.54) were sensitive to acute abstinence. In experiment 2 go/no-go performance was improved (MD 1.12, 95{\%} CI: 0.16-2.08) and craving was lower (RC -18.59, 95{\%} CI: -24.63 to -12.55) smokers abstinent overnight receiving NRT compared with placebo. There was no clear evidence that N-back (MD -0.25, 95{\%} CI: -1.45 to 0.94), delay discounting (MD 0.01, 95{\%} CI: -0.002 to 0.004) or dot probe performance (MD -0.49, 95{\%} CI: -1.61 to -0.64) were sensitive to NRT.CONCLUSIONS: Findings from two experiments converge to suggest that abstinence in smokers reliably increases ambulatory craving assessments and, to a lesser extent, decreases go/no-go task performance. These findings can be utilized in the development of an experimental medicine model to test novel treatments for smoking cessation.",
keywords = "Tobacco withdrawal, Tobacco abstinence, Cognitive performance, Ecological momentary assessment, Smoking cessation, Experimental medicine model",
author = "Meryem Grabski and Curran, {H Valerie} and Nutt, {David J} and Husbands, {Stephen M} and Ferguson, {Stuart G} and Munaf{\`o}, {Marcus R}",
year = "2020",
month = "1",
day = "1",
doi = "10.1016/j.drugalcdep.2019.107720",
language = "English",
volume = "206",
pages = "107720",
journal = "Drug and Alcohol Dependence",
issn = "0376-8716",
publisher = "Elsevier Sequoia",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - The development and validation of a human screening model of tobacco abstinence

AU - Grabski, Meryem

AU - Curran, H Valerie

AU - Nutt, David J

AU - Husbands, Stephen M

AU - Ferguson, Stuart G

AU - Munafò, Marcus R

PY - 2020/1/1

Y1 - 2020/1/1

N2 - INTRODUCTION: Given the low efficacy of smoking cessation methods, an experimental medicine model indicating smoking abstinence would be of great benefit to the development of new treatments. Hence the sensitivity of cognitive tasks and ambulatory craving measures to smoking abstinence were investigated.METHODS: Cognitive tasks and ambulatory ratings of craving were assessed for sensitivity to acute abstinence (experiment 1), and nicotine replacement therapy administration (NRT) (experiment 2).RESULTS: In experiment 1 go/no-go performance was improved (Mean Difference [MD] -0.99, 95% CI: -1.90 to -0.08) and craving was lower (Regression Coefficient [RC] -33.39, 95% CI: -39.96 to -26.82) in satiated compared with abstinent smokers. There was no clear evidence that N-back (MD 0.64, 95% CI: -0.42 to 2.51), delay discounting (MD 0.01, 95% CI: 0.001 to 0.005) or dot probe performance (MD 0.61, 95% CI: -0.87 to 1.54) were sensitive to acute abstinence. In experiment 2 go/no-go performance was improved (MD 1.12, 95% CI: 0.16-2.08) and craving was lower (RC -18.59, 95% CI: -24.63 to -12.55) smokers abstinent overnight receiving NRT compared with placebo. There was no clear evidence that N-back (MD -0.25, 95% CI: -1.45 to 0.94), delay discounting (MD 0.01, 95% CI: -0.002 to 0.004) or dot probe performance (MD -0.49, 95% CI: -1.61 to -0.64) were sensitive to NRT.CONCLUSIONS: Findings from two experiments converge to suggest that abstinence in smokers reliably increases ambulatory craving assessments and, to a lesser extent, decreases go/no-go task performance. These findings can be utilized in the development of an experimental medicine model to test novel treatments for smoking cessation.

AB - INTRODUCTION: Given the low efficacy of smoking cessation methods, an experimental medicine model indicating smoking abstinence would be of great benefit to the development of new treatments. Hence the sensitivity of cognitive tasks and ambulatory craving measures to smoking abstinence were investigated.METHODS: Cognitive tasks and ambulatory ratings of craving were assessed for sensitivity to acute abstinence (experiment 1), and nicotine replacement therapy administration (NRT) (experiment 2).RESULTS: In experiment 1 go/no-go performance was improved (Mean Difference [MD] -0.99, 95% CI: -1.90 to -0.08) and craving was lower (Regression Coefficient [RC] -33.39, 95% CI: -39.96 to -26.82) in satiated compared with abstinent smokers. There was no clear evidence that N-back (MD 0.64, 95% CI: -0.42 to 2.51), delay discounting (MD 0.01, 95% CI: 0.001 to 0.005) or dot probe performance (MD 0.61, 95% CI: -0.87 to 1.54) were sensitive to acute abstinence. In experiment 2 go/no-go performance was improved (MD 1.12, 95% CI: 0.16-2.08) and craving was lower (RC -18.59, 95% CI: -24.63 to -12.55) smokers abstinent overnight receiving NRT compared with placebo. There was no clear evidence that N-back (MD -0.25, 95% CI: -1.45 to 0.94), delay discounting (MD 0.01, 95% CI: -0.002 to 0.004) or dot probe performance (MD -0.49, 95% CI: -1.61 to -0.64) were sensitive to NRT.CONCLUSIONS: Findings from two experiments converge to suggest that abstinence in smokers reliably increases ambulatory craving assessments and, to a lesser extent, decreases go/no-go task performance. These findings can be utilized in the development of an experimental medicine model to test novel treatments for smoking cessation.

KW - Tobacco withdrawal

KW - Tobacco abstinence

KW - Cognitive performance

KW - Ecological momentary assessment

KW - Smoking cessation

KW - Experimental medicine model

U2 - 10.1016/j.drugalcdep.2019.107720

DO - 10.1016/j.drugalcdep.2019.107720

M3 - Article

C2 - 31790979

VL - 206

SP - 107720

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

SN - 0376-8716

ER -