The Development of a Chewing Robot to Simulate Human Mastication to Quantify the Release of Agents from Chewing Gums in vitro

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Currently there is no chewing simulator that closely replicates the human chewing motion to quantify the release of agents from chewing gums. This study presents a newly developed chewing robot capable of closely replicating the human chewing motion in a closed environment. The release of xylitol from commercially available chewing gum has been quantified and validated using both human participants and the chewing robot. Saliva and artificial saliva solutions respectively were collected after 5, 10, 15 and 20 minutes of continuous chewing. The amount of xylitol that was released from the chewing gum was determined. The greatest amount of release was during the first 5 minutes of chewing and after 20 minutes of chewing there was only a low amount of xylitol remaining in the gum bolus, irrespective of the chewing method used. The chewing robot demonstrated the same release rate of xylitol as human participants. This result shows that the chewing robot could be used to develop medicated chewing gums in vitro. This would reduce the cost of developing medicated chewing gums whilst also providing opportunities for pharmaceutical companies to tailor drug delivery to patients needs in a controlled, safe and user-friendly manner, improving patient care and outcome.
Original languageEnglish
JournalInternational Journal of Pharmaceutics
Publication statusIn preparation - 15 May 2019


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