The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells

Lyudmila Turyanska*, Tracey D. Bradshaw, Mei Li, Philip Bardelang, William C. Drewe, Michael W. Fay, Stephen Mann, Amalia Patane, Neil R. Thomas

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Abstract

We report the effects induced by near-infrared apoferritin-PbS (AFt-PbS) nanocomposites on cell cycle progression in non-tumorigenic and cancerous human cells. By using flow cytometry and Annexin V assay, we show that the cell cycle of non-tumorigenic cells is not altered by exposure to AFt-PbS nanoparticles at concentrations up to 1 mg mL(-1). In contrast, exposure of human-derived breast cancer cell lines to AFt-PbS at concentrations > 0.2 mg mL(-1) triggers apoptotic cell death. The selective death of cancerous cells and the near-infrared fluorescence properties of AFt-PbS could be exploited in both nanomedicine and in vivo imaging studies.

Original languageEnglish
Pages (from-to)660-665
Number of pages6
JournalJournal of Materials Chemistry
Volume22
Issue number2
DOIs
Publication statusPublished - 14 Jan 2012

Keywords

  • QUANTUM DOTS
  • MANUFACTURED NANOPARTICLES
  • SILVER NANOPARTICLES
  • IN-VITRO
  • CYTOTOXICITY
  • TOXICITY
  • BIOCOMPATIBILITY
  • FERRITIN
  • NANOTECHNOLOGY
  • APOPTOSIS

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