The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells

Lyudmila Turyanska; Tracey D. Bradshaw; Mei Li; Philip Bardelang; William C. Drewe; Michael W. Fay; Stephen Mann; Amalia Patane; Neil R. Thomas

doi:10.1039/c1jm13563e

The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells

Lyudmila Turyanska^*, Tracey D. Bradshaw, Mei Li, Philip Bardelang, William C. Drewe, Michael W. Fay, Stephen Mann, Amalia Patane, Neil R. Thomas

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

16 Citations (Scopus)

Abstract

We report the effects induced by near-infrared apoferritin-PbS (AFt-PbS) nanocomposites on cell cycle progression in non-tumorigenic and cancerous human cells. By using flow cytometry and Annexin V assay, we show that the cell cycle of non-tumorigenic cells is not altered by exposure to AFt-PbS nanoparticles at concentrations up to 1 mg mL(-1). In contrast, exposure of human-derived breast cancer cell lines to AFt-PbS at concentrations > 0.2 mg mL(-1) triggers apoptotic cell death. The selective death of cancerous cells and the near-infrared fluorescence properties of AFt-PbS could be exploited in both nanomedicine and in vivo imaging studies.

Original language	English
Pages (from-to)	660-665
Number of pages	6
Journal	Journal of Materials Chemistry
Volume	22
Issue number	2
DOIs	https://doi.org/10.1039/c1jm13563e
Publication status	Published - 14 Jan 2012

Research Groups and Themes

Inorganic & Materials

Keywords

QUANTUM DOTS
MANUFACTURED NANOPARTICLES
SILVER NANOPARTICLES
IN-VITRO
CYTOTOXICITY
TOXICITY
BIOCOMPATIBILITY
FERRITIN
NANOTECHNOLOGY
APOPTOSIS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c1jm13563e

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@article{fba8b6b9e2cb409e814100a892377cc7,

title = "The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells",

abstract = "We report the effects induced by near-infrared apoferritin-PbS (AFt-PbS) nanocomposites on cell cycle progression in non-tumorigenic and cancerous human cells. By using flow cytometry and Annexin V assay, we show that the cell cycle of non-tumorigenic cells is not altered by exposure to AFt-PbS nanoparticles at concentrations up to 1 mg mL(-1). In contrast, exposure of human-derived breast cancer cell lines to AFt-PbS at concentrations > 0.2 mg mL(-1) triggers apoptotic cell death. The selective death of cancerous cells and the near-infrared fluorescence properties of AFt-PbS could be exploited in both nanomedicine and in vivo imaging studies.",

keywords = "QUANTUM DOTS, MANUFACTURED NANOPARTICLES, SILVER NANOPARTICLES, IN-VITRO, CYTOTOXICITY, TOXICITY, BIOCOMPATIBILITY, FERRITIN, NANOTECHNOLOGY, APOPTOSIS",

author = "Lyudmila Turyanska and Bradshaw, \{Tracey D.\} and Mei Li and Philip Bardelang and Drewe, \{William C.\} and Fay, \{Michael W.\} and Stephen Mann and Amalia Patane and Thomas, \{Neil R.\}",

year = "2012",

month = jan,

day = "14",

doi = "10.1039/c1jm13563e",

language = "English",

volume = "22",

pages = "660--665",

journal = "Journal of Materials Chemistry",

issn = "0959-9428",

publisher = "Royal Society of Chemistry",

number = "2",

}

TY - JOUR

T1 - The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells

AU - Turyanska, Lyudmila

AU - Bradshaw, Tracey D.

AU - Li, Mei

AU - Bardelang, Philip

AU - Drewe, William C.

AU - Fay, Michael W.

AU - Mann, Stephen

AU - Patane, Amalia

AU - Thomas, Neil R.

PY - 2012/1/14

Y1 - 2012/1/14

N2 - We report the effects induced by near-infrared apoferritin-PbS (AFt-PbS) nanocomposites on cell cycle progression in non-tumorigenic and cancerous human cells. By using flow cytometry and Annexin V assay, we show that the cell cycle of non-tumorigenic cells is not altered by exposure to AFt-PbS nanoparticles at concentrations up to 1 mg mL(-1). In contrast, exposure of human-derived breast cancer cell lines to AFt-PbS at concentrations > 0.2 mg mL(-1) triggers apoptotic cell death. The selective death of cancerous cells and the near-infrared fluorescence properties of AFt-PbS could be exploited in both nanomedicine and in vivo imaging studies.

AB - We report the effects induced by near-infrared apoferritin-PbS (AFt-PbS) nanocomposites on cell cycle progression in non-tumorigenic and cancerous human cells. By using flow cytometry and Annexin V assay, we show that the cell cycle of non-tumorigenic cells is not altered by exposure to AFt-PbS nanoparticles at concentrations up to 1 mg mL(-1). In contrast, exposure of human-derived breast cancer cell lines to AFt-PbS at concentrations > 0.2 mg mL(-1) triggers apoptotic cell death. The selective death of cancerous cells and the near-infrared fluorescence properties of AFt-PbS could be exploited in both nanomedicine and in vivo imaging studies.

KW - QUANTUM DOTS

KW - MANUFACTURED NANOPARTICLES

KW - SILVER NANOPARTICLES

KW - IN-VITRO

KW - CYTOTOXICITY

KW - TOXICITY

KW - BIOCOMPATIBILITY

KW - FERRITIN

KW - NANOTECHNOLOGY

KW - APOPTOSIS

U2 - 10.1039/c1jm13563e

DO - 10.1039/c1jm13563e

M3 - Article (Academic Journal)

SN - 0959-9428

VL - 22

SP - 660

EP - 665

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 2

ER -

The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells

Abstract

Research Groups and Themes

Keywords

UN SDGs

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