The distinguishable DNA whole genome methylation profile of 2 cases of pediatric precursor B acute lymphoblastic leukaemia (BCP ALL) with prodromal, preleukemic phase: A case report

Radosław Chaber; Artur Gurgul; Grażyna Wróbel; Anna Tomoń; Sylwia Paszek; Natalia Potocka; Olga Haus; Monika Lejman; Kornelia Łach; Tomasz Szmatoła; Igor Jasielczuk; Blanka Rybka; Renata Ryczan-Krawczyk; Sylwia Stąpor; Krzysztof Ciebiera; Christopher J Arthur; Izabela Zawlik

doi:10.1097/MD.0000000000012763

The distinguishable DNA whole genome methylation profile of 2 cases of pediatric precursor B acute lymphoblastic leukaemia (BCP ALL) with prodromal, preleukemic phase: A case report

Radosław Chaber, Artur Gurgul, Grażyna Wróbel, Anna Tomoń, Sylwia Paszek, Natalia Potocka, Olga Haus, Monika Lejman, Kornelia Łach, Tomasz Szmatoła, Igor Jasielczuk, Blanka Rybka, Renata Ryczan-Krawczyk, Sylwia Stąpor, Krzysztof Ciebiera, Christopher J Arthur, Izabela Zawlik

School of Chemistry

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Abstract

RATIONALE: A prolonged, prodromal phase before definitive paediatric precursor B acute lymphoblastic leukaemia (BCP ALL) diagnosis is rarely observed.

PATIENTS CONCERNS: In the first, the patient presented with an aplastic preleukemic phase, whilst the second presented with a rheumatic-like preliminary phase.

DIAGNOSES: The case reports of two patients with BCP ALL with a prodromal phase lasting a few weeks are presented.

INTERVENTIONS AND OUTCOMES: DNA whole genome profile methylation analysis of bone marrow cells obtained at diagnosis revealed a pattern of methylation that was readily distinguishable from both healthy and standard course BCP ALL bone marrow samples.

LESSONS: The biological implication of this observation remains unclear, with many differentially methylated loci involved in many processes like neurogenesis, cell projection organization and adhesion along with leucocyte activation and apoptosis. The prevalence and clinical significance of these methylation changes is unknown but this data indicates that the epigenetic basis of BCP ALL with a prolonged, prodromal phase requires a more detailed assessment.

Original language	English
Article number	e12763
Number of pages	9
Journal	Medicine (Baltimore)
Volume	97
Issue number	42
DOIs	https://doi.org/10.1097/MD.0000000000012763
Publication status	Published - 1 Oct 2018

Keywords

Acute Disease
Bone Marrow Cells/metabolism
Child
DNA Methylation
Humans
Male
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics
Prodromal Symptoms

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Chaber, R., Gurgul, A., Wróbel, G., Tomoń, A., Paszek, S., Potocka, N., Haus, O., Lejman, M., Łach, K., Szmatoła, T., Jasielczuk, I., Rybka, B., Ryczan-Krawczyk, R., Stąpor, S., Ciebiera, K., Arthur, C. J., & Zawlik, I. (2018). The distinguishable DNA whole genome methylation profile of 2 cases of pediatric precursor B acute lymphoblastic leukaemia (BCP ALL) with prodromal, preleukemic phase: A case report. Medicine (Baltimore), 97(42), Article e12763. https://doi.org/10.1097/MD.0000000000012763

@article{bcce7b97eb844b2fb742171aebaa0282,

title = "The distinguishable DNA whole genome methylation profile of 2 cases of pediatric precursor B acute lymphoblastic leukaemia (BCP ALL) with prodromal, preleukemic phase: A case report",

abstract = "RATIONALE: A prolonged, prodromal phase before definitive paediatric precursor B acute lymphoblastic leukaemia (BCP ALL) diagnosis is rarely observed.PATIENTS CONCERNS: In the first, the patient presented with an aplastic preleukemic phase, whilst the second presented with a rheumatic-like preliminary phase.DIAGNOSES: The case reports of two patients with BCP ALL with a prodromal phase lasting a few weeks are presented.INTERVENTIONS AND OUTCOMES: DNA whole genome profile methylation analysis of bone marrow cells obtained at diagnosis revealed a pattern of methylation that was readily distinguishable from both healthy and standard course BCP ALL bone marrow samples.LESSONS: The biological implication of this observation remains unclear, with many differentially methylated loci involved in many processes like neurogenesis, cell projection organization and adhesion along with leucocyte activation and apoptosis. The prevalence and clinical significance of these methylation changes is unknown but this data indicates that the epigenetic basis of BCP ALL with a prolonged, prodromal phase requires a more detailed assessment.",

keywords = "Acute Disease, Bone Marrow Cells/metabolism, Child, DNA Methylation, Humans, Male, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics, Prodromal Symptoms",

author = "Rados{\l}aw Chaber and Artur Gurgul and Gra{\.z}yna Wr{\'o}bel and Anna Tomo{\'n} and Sylwia Paszek and Natalia Potocka and Olga Haus and Monika Lejman and Kornelia {\L}ach and Tomasz Szmato{\l}a and Igor Jasielczuk and Blanka Rybka and Renata Ryczan-Krawczyk and Sylwia St{\c a}por and Krzysztof Ciebiera and Arthur, {Christopher J} and Izabela Zawlik",

year = "2018",

month = oct,

day = "1",

doi = "10.1097/MD.0000000000012763",

language = "English",

volume = "97",

journal = "Medicine (Baltimore)",

issn = "0025-7974",

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Chaber, R, Gurgul, A, Wróbel, G, Tomoń, A, Paszek, S, Potocka, N, Haus, O, Lejman, M, Łach, K, Szmatoła, T, Jasielczuk, I, Rybka, B, Ryczan-Krawczyk, R, Stąpor, S, Ciebiera, K, Arthur, CJ & Zawlik, I 2018, 'The distinguishable DNA whole genome methylation profile of 2 cases of pediatric precursor B acute lymphoblastic leukaemia (BCP ALL) with prodromal, preleukemic phase: A case report', Medicine (Baltimore), vol. 97, no. 42, e12763. https://doi.org/10.1097/MD.0000000000012763

The distinguishable DNA whole genome methylation profile of 2 cases of pediatric precursor B acute lymphoblastic leukaemia (BCP ALL) with prodromal, preleukemic phase: A case report. / Chaber, Radosław; Gurgul, Artur; Wróbel, Grażyna et al.
In: Medicine (Baltimore), Vol. 97, No. 42, e12763, 01.10.2018.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - The distinguishable DNA whole genome methylation profile of 2 cases of pediatric precursor B acute lymphoblastic leukaemia (BCP ALL) with prodromal, preleukemic phase

T2 - A case report

AU - Chaber, Radosław

AU - Gurgul, Artur

AU - Wróbel, Grażyna

AU - Tomoń, Anna

AU - Paszek, Sylwia

AU - Potocka, Natalia

AU - Haus, Olga

AU - Lejman, Monika

AU - Łach, Kornelia

AU - Szmatoła, Tomasz

AU - Jasielczuk, Igor

AU - Rybka, Blanka

AU - Ryczan-Krawczyk, Renata

AU - Stąpor, Sylwia

AU - Ciebiera, Krzysztof

AU - Arthur, Christopher J

AU - Zawlik, Izabela

PY - 2018/10/1

Y1 - 2018/10/1

N2 - RATIONALE: A prolonged, prodromal phase before definitive paediatric precursor B acute lymphoblastic leukaemia (BCP ALL) diagnosis is rarely observed.PATIENTS CONCERNS: In the first, the patient presented with an aplastic preleukemic phase, whilst the second presented with a rheumatic-like preliminary phase.DIAGNOSES: The case reports of two patients with BCP ALL with a prodromal phase lasting a few weeks are presented.INTERVENTIONS AND OUTCOMES: DNA whole genome profile methylation analysis of bone marrow cells obtained at diagnosis revealed a pattern of methylation that was readily distinguishable from both healthy and standard course BCP ALL bone marrow samples.LESSONS: The biological implication of this observation remains unclear, with many differentially methylated loci involved in many processes like neurogenesis, cell projection organization and adhesion along with leucocyte activation and apoptosis. The prevalence and clinical significance of these methylation changes is unknown but this data indicates that the epigenetic basis of BCP ALL with a prolonged, prodromal phase requires a more detailed assessment.

AB - RATIONALE: A prolonged, prodromal phase before definitive paediatric precursor B acute lymphoblastic leukaemia (BCP ALL) diagnosis is rarely observed.PATIENTS CONCERNS: In the first, the patient presented with an aplastic preleukemic phase, whilst the second presented with a rheumatic-like preliminary phase.DIAGNOSES: The case reports of two patients with BCP ALL with a prodromal phase lasting a few weeks are presented.INTERVENTIONS AND OUTCOMES: DNA whole genome profile methylation analysis of bone marrow cells obtained at diagnosis revealed a pattern of methylation that was readily distinguishable from both healthy and standard course BCP ALL bone marrow samples.LESSONS: The biological implication of this observation remains unclear, with many differentially methylated loci involved in many processes like neurogenesis, cell projection organization and adhesion along with leucocyte activation and apoptosis. The prevalence and clinical significance of these methylation changes is unknown but this data indicates that the epigenetic basis of BCP ALL with a prolonged, prodromal phase requires a more detailed assessment.

KW - Acute Disease

KW - Bone Marrow Cells/metabolism

KW - Child

KW - DNA Methylation

KW - Humans

KW - Male

KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics

KW - Prodromal Symptoms

U2 - 10.1097/MD.0000000000012763

DO - 10.1097/MD.0000000000012763

M3 - Article (Academic Journal)

C2 - 30334962

SN - 0025-7974

VL - 97

JO - Medicine (Baltimore)

JF - Medicine (Baltimore)

IS - 42

M1 - e12763

ER -

The distinguishable DNA whole genome methylation profile of 2 cases of pediatric precursor B acute lymphoblastic leukaemia (BCP ALL) with prodromal, preleukemic phase: A case report

Abstract

Keywords

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