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The dynamics between limited-term and lifelong coinfecting bacterial parasites in wild rodent hosts

Research output: Contribution to journalReview article

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The dynamics between limited-term and lifelong coinfecting bacterial parasites in wild rodent hosts. / Eidelman, Anat; Cohen, Carmit; Navarro-Castilla, Álvaro ; Filler, Serina; Gutiérrez, Ricardo ; Bar-Shira, Enav ; Shachar, Naama ; Garrido, Mario; Halle, Snir ; Romach, Yoav ; Barja, Isabel ; Tasker, Severine; Harrus, Shimon ; Friedman, Aharon ; Hawlena, Hadas.

In: Journal of Experimental Biology, Vol. 222, 31.07.2019.

Research output: Contribution to journalReview article

Harvard

Eidelman, A, Cohen, C, Navarro-Castilla, Á, Filler, S, Gutiérrez, R, Bar-Shira, E, Shachar, N, Garrido, M, Halle, S, Romach, Y, Barja, I, Tasker, S, Harrus, S, Friedman, A & Hawlena, H 2019, 'The dynamics between limited-term and lifelong coinfecting bacterial parasites in wild rodent hosts', Journal of Experimental Biology, vol. 222. https://doi.org/10.1242/jeb.203562

APA

Eidelman, A., Cohen, C., Navarro-Castilla, Á., Filler, S., Gutiérrez, R., Bar-Shira, E., ... Hawlena, H. (2019). The dynamics between limited-term and lifelong coinfecting bacterial parasites in wild rodent hosts. Journal of Experimental Biology, 222. https://doi.org/10.1242/jeb.203562

Vancouver

Eidelman A, Cohen C, Navarro-Castilla Á, Filler S, Gutiérrez R, Bar-Shira E et al. The dynamics between limited-term and lifelong coinfecting bacterial parasites in wild rodent hosts. Journal of Experimental Biology. 2019 Jul 31;222. https://doi.org/10.1242/jeb.203562

Author

Eidelman, Anat ; Cohen, Carmit ; Navarro-Castilla, Álvaro ; Filler, Serina ; Gutiérrez, Ricardo ; Bar-Shira, Enav ; Shachar, Naama ; Garrido, Mario ; Halle, Snir ; Romach, Yoav ; Barja, Isabel ; Tasker, Severine ; Harrus, Shimon ; Friedman, Aharon ; Hawlena, Hadas. / The dynamics between limited-term and lifelong coinfecting bacterial parasites in wild rodent hosts. In: Journal of Experimental Biology. 2019 ; Vol. 222.

Bibtex

@article{162d0f2015824b819bb3468df807030d,
title = "The dynamics between limited-term and lifelong coinfecting bacterial parasites in wild rodent hosts",
abstract = "Interactions between coinfecting parasites may take various forms, either direct or indirect, facilitative or competitive, and may be mediated by either bottom-up or top-down mechanisms. Although each form of interaction leads to different evolutionary and ecological outcomes, it is challenging to tease them apart throughout the infection period. To establish the first step towards a mechanistic understanding of the interactions between coinfecting limited-term bacterial parasites and lifelong bacterial parasites, we studied the coinfection of Bartonella sp. (limited-term) and Mycoplasma sp. (lifelong), which commonly co-occur in wild rodents. We infected Bartonella- and Mycoplasma-free rodents with each species, and simultaneously with both, and quantified the infection dynamics and host responses. Bartonella benefited from the interaction; its infection load decreased more slowly in coinfected rodents than in rodents infected with Bartonella alone. There were no indications for bottom-up effects, but coinfected rodents experienced various changes, depending on the infection stage, in their body mass, stress levels and activity pattern, which may further affect bacterial replication and transmission. Interestingly, the infection dynamics and changes in the average coinfected rodent traits were more similar to the chronic effects of Mycoplasma infection, whereas coinfection uniquely impaired the host's physiological and behavioral stability. These results suggest that parasites with distinct life history strategies may interact, and their interaction may be asymmetric, non-additive, multifaceted and dynamic through time. Because multiple, sometimes contrasting, forms of interactions are simultaneously at play and their relative importance alternates throughout the course of infection, the overall outcome may change under different ecological conditions.",
keywords = "Coinfection, Concomitant infections, Mixed infections, Multiple parasites, Within-host competition, Within-host facilitation",
author = "Anat Eidelman and Carmit Cohen and {\'A}lvaro Navarro-Castilla and Serina Filler and Ricardo Guti{\'e}rrez and Enav Bar-Shira and Naama Shachar and Mario Garrido and Snir Halle and Yoav Romach and Isabel Barja and Severine Tasker and Shimon Harrus and Aharon Friedman and Hadas Hawlena",
year = "2019",
month = "7",
day = "31",
doi = "10.1242/jeb.203562",
language = "English",
volume = "222",
journal = "Journal of Experimental Biology",
issn = "0022-0949",
publisher = "Company of Biologists Ltd",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - The dynamics between limited-term and lifelong coinfecting bacterial parasites in wild rodent hosts

AU - Eidelman, Anat

AU - Cohen, Carmit

AU - Navarro-Castilla, Álvaro

AU - Filler, Serina

AU - Gutiérrez, Ricardo

AU - Bar-Shira, Enav

AU - Shachar, Naama

AU - Garrido, Mario

AU - Halle, Snir

AU - Romach, Yoav

AU - Barja, Isabel

AU - Tasker, Severine

AU - Harrus, Shimon

AU - Friedman, Aharon

AU - Hawlena, Hadas

PY - 2019/7/31

Y1 - 2019/7/31

N2 - Interactions between coinfecting parasites may take various forms, either direct or indirect, facilitative or competitive, and may be mediated by either bottom-up or top-down mechanisms. Although each form of interaction leads to different evolutionary and ecological outcomes, it is challenging to tease them apart throughout the infection period. To establish the first step towards a mechanistic understanding of the interactions between coinfecting limited-term bacterial parasites and lifelong bacterial parasites, we studied the coinfection of Bartonella sp. (limited-term) and Mycoplasma sp. (lifelong), which commonly co-occur in wild rodents. We infected Bartonella- and Mycoplasma-free rodents with each species, and simultaneously with both, and quantified the infection dynamics and host responses. Bartonella benefited from the interaction; its infection load decreased more slowly in coinfected rodents than in rodents infected with Bartonella alone. There were no indications for bottom-up effects, but coinfected rodents experienced various changes, depending on the infection stage, in their body mass, stress levels and activity pattern, which may further affect bacterial replication and transmission. Interestingly, the infection dynamics and changes in the average coinfected rodent traits were more similar to the chronic effects of Mycoplasma infection, whereas coinfection uniquely impaired the host's physiological and behavioral stability. These results suggest that parasites with distinct life history strategies may interact, and their interaction may be asymmetric, non-additive, multifaceted and dynamic through time. Because multiple, sometimes contrasting, forms of interactions are simultaneously at play and their relative importance alternates throughout the course of infection, the overall outcome may change under different ecological conditions.

AB - Interactions between coinfecting parasites may take various forms, either direct or indirect, facilitative or competitive, and may be mediated by either bottom-up or top-down mechanisms. Although each form of interaction leads to different evolutionary and ecological outcomes, it is challenging to tease them apart throughout the infection period. To establish the first step towards a mechanistic understanding of the interactions between coinfecting limited-term bacterial parasites and lifelong bacterial parasites, we studied the coinfection of Bartonella sp. (limited-term) and Mycoplasma sp. (lifelong), which commonly co-occur in wild rodents. We infected Bartonella- and Mycoplasma-free rodents with each species, and simultaneously with both, and quantified the infection dynamics and host responses. Bartonella benefited from the interaction; its infection load decreased more slowly in coinfected rodents than in rodents infected with Bartonella alone. There were no indications for bottom-up effects, but coinfected rodents experienced various changes, depending on the infection stage, in their body mass, stress levels and activity pattern, which may further affect bacterial replication and transmission. Interestingly, the infection dynamics and changes in the average coinfected rodent traits were more similar to the chronic effects of Mycoplasma infection, whereas coinfection uniquely impaired the host's physiological and behavioral stability. These results suggest that parasites with distinct life history strategies may interact, and their interaction may be asymmetric, non-additive, multifaceted and dynamic through time. Because multiple, sometimes contrasting, forms of interactions are simultaneously at play and their relative importance alternates throughout the course of infection, the overall outcome may change under different ecological conditions.

KW - Coinfection

KW - Concomitant infections

KW - Mixed infections

KW - Multiple parasites

KW - Within-host competition

KW - Within-host facilitation

U2 - 10.1242/jeb.203562

DO - 10.1242/jeb.203562

M3 - Review article

VL - 222

JO - Journal of Experimental Biology

JF - Journal of Experimental Biology

SN - 0022-0949

ER -