1. (1) Seven healthy normolipaemic men aged 28–46 years (mean 33 years) were studied for four weeks on their usual diet, the mean polyunsaturated to saturated fat (P : S) ratio of which was approximately 0.23 and the cholesterol content 667 mg/day, and for four weeks on an isocaloric diet, containing similar proportions of protein, carbohydrate and fat, but with a mean P : S ratio of approximately 2.82 and a cholesterol content of 112 mg/day. 2. (2) Total serum cholesterol levels decreased by 18.7 ± 5.2% (mean ± SEM) on the polyunsaturated fat (PUF) diet. This was attributable to a similar reduction in serum low density lipoprotein (LDL) cholesterol. Serum very low density lipoprotein (VLDL) cholesterol showed no clear change. Total serum triglyceride levels decreased by 19.7 ± 7.1% due to a reduction in both serum VLDL and LDL triglyceride concentration. 3. (3) Total serum apolipoprotein B concentration fell by 23 ± 2.6% during the PUF diet. There was a decrease of similar magnitude in serum LDL apolipoprotein B, but no sustained effect on serum VLDL apolipoprotein B. 4. (4) Serum VLDL and LDL lipid to apolipoprotein B ratios did not change significantly during the study. 5. (5) Serum triglyceride fatty acid composition significantly altered during the PUF diet. The percentage of linoleic acid rose from 16 ± 0.90% to 36 ± 0.89%, whilst the percentage of combined saturated and monounsaturated acids fell correspondingly. These changes took place within 2 days of starting the PUF diet.
|Translated title of the contribution||The effect of a low-cholesterol, high-polyunsaturate diet on serum lipid levels, apolipoprotein B levels and triglyceride fatty acid composition|
|Pages (from-to)||465 - 475|
|Number of pages||11|
|Publication status||Published - Aug 1977|