The effect of body mass index at diagnosis on survival of patients with squamous cell head and neck carcinoma

Roberta Pastorino; Denise Pires Marafon; Nicolò Lentini; Ilda Hoxhaj; Adriano Grossi; Luca Giraldi; Antonella Rondinò; Gabriella Cadoni; Jerry Polesel; Diego Serraino; Carlo La Vecchia; Werner Garavello; Cristina Canova; Lorenzo Richiardi; Jolanta Lissowska; Tamas Pandics; Tom Dudding; Andy Ness; Steve Thomas; Miranda Pring; Karl Kelsey; Michael McClean; Patrick Bradshaw; Zuo-Feng Zhang; Hal Morgenstern; Laura Rozek; Gregory Wolf; Andrew Olshan; Geoffrey Liu; Rayjean Hung; Marta Vilensky; Marcos Brasilino de Carvalho; Rossana Verónica Mendonza López; Victor Wunsch-Filho; Paolo Boffetta; Mia Hashibe; Yuan-Chin Amy Lee; Stefania Boccia

doi:10.62347/UUXK7608

The effect of body mass index at diagnosis on survival of patients with squamous cell head and neck carcinoma

Roberta Pastorino, Denise Pires Marafon, Nicolò Lentini, Ilda Hoxhaj, Adriano Grossi, Luca Giraldi, Antonella Rondinò, Gabriella Cadoni, Jerry Polesel, Diego Serraino, Carlo La Vecchia, Werner Garavello, Cristina Canova, Lorenzo Richiardi, Jolanta Lissowska, Tamas Pandics, Tom Dudding, Andy Ness, Steve Thomas, Miranda PringKarl Kelsey, Michael McClean, Patrick Bradshaw, Zuo-Feng Zhang, Hal Morgenstern, Laura Rozek, Gregory Wolf, Andrew Olshan, Geoffrey Liu, Rayjean Hung, Marta Vilensky, Marcos Brasilino de Carvalho, Rossana Verónica Mendonza López, Victor Wunsch-Filho, Paolo Boffetta, Mia Hashibe, Yuan-Chin Amy Lee, Stefania Boccia

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

The aim of this study is to investigate the prognostic role of body mass index (BMI) on survival from head and neck cancer (HNC). We performed a pooled analysis of studies included in the International Head and Neck Cancer Epidemiology consortium. We used Cox proportional hazards models to estimate the adjusted hazard ratios (HR) for overall survival and HNC-specific survival, and we stratified the results according to cancer site. The study included 10,177 patients from 10 studies worldwide. Underweight patients had lower overall survival (HR=1.69, 95% CI: 1.31-2.19) respect to those having normal weight with consistent results across the HNC sites. Overweight and obese patients had a favourable HNC-specific survival (HR=0.77 (95% CI: 0.70-0.84) and HR=0.80 (95% CI: 0.76-0.84), respectively), with heterogenous results according to HNC site. Our findings show that high BMI values at cancer diagnosis improved the survival rates in patients with HNC, especially among smokers. This association may be explained by residual confounding, reverse causation, and collider stratification bias, but may also suggest that a nutritional reserve may help patients survive HNC cancer.

Original language	English
Pages (from-to)	5411-5426
Number of pages	16
Journal	American Journal of Cancer Research
Volume	14
Issue number	11
Early online date	15 Nov 2024
DOIs	https://doi.org/10.62347/UUXK7608
Publication status	Published - 30 Nov 2024

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Pastorino, R., Pires Marafon, D., Lentini, N., Hoxhaj, I., Grossi, A., Giraldi, L., Rondinò, A., Cadoni, G., Polesel, J., Serraino, D., La Vecchia, C., Garavello, W., Canova, C., Richiardi, L., Lissowska, J., Pandics, T., Dudding, T., Ness, A., Thomas, S., ... Boccia, S. (2024). The effect of body mass index at diagnosis on survival of patients with squamous cell head and neck carcinoma. American Journal of Cancer Research, 14(11), 5411-5426. https://doi.org/10.62347/UUXK7608

@article{71880ce02eaf4d5b8f4bae387249affd,

title = "The effect of body mass index at diagnosis on survival of patients with squamous cell head and neck carcinoma",

abstract = "The aim of this study is to investigate the prognostic role of body mass index (BMI) on survival from head and neck cancer (HNC). We performed a pooled analysis of studies included in the International Head and Neck Cancer Epidemiology consortium. We used Cox proportional hazards models to estimate the adjusted hazard ratios (HR) for overall survival and HNC-specific survival, and we stratified the results according to cancer site. The study included 10,177 patients from 10 studies worldwide. Underweight patients had lower overall survival (HR=1.69, 95\% CI: 1.31-2.19) respect to those having normal weight with consistent results across the HNC sites. Overweight and obese patients had a favourable HNC-specific survival (HR=0.77 (95\% CI: 0.70-0.84) and HR=0.80 (95\% CI: 0.76-0.84), respectively), with heterogenous results according to HNC site. Our findings show that high BMI values at cancer diagnosis improved the survival rates in patients with HNC, especially among smokers. This association may be explained by residual confounding, reverse causation, and collider stratification bias, but may also suggest that a nutritional reserve may help patients survive HNC cancer.",

author = "Roberta Pastorino and \{Pires Marafon\}, Denise and Nicol{\`o} Lentini and Ilda Hoxhaj and Adriano Grossi and Luca Giraldi and Antonella Rondin{\`o} and Gabriella Cadoni and Jerry Polesel and Diego Serraino and \{La Vecchia\}, Carlo and Werner Garavello and Cristina Canova and Lorenzo Richiardi and Jolanta Lissowska and Tamas Pandics and Tom Dudding and Andy Ness and Steve Thomas and Miranda Pring and Karl Kelsey and Michael McClean and Patrick Bradshaw and Zuo-Feng Zhang and Hal Morgenstern and Laura Rozek and Gregory Wolf and Andrew Olshan and Geoffrey Liu and Rayjean Hung and Marta Vilensky and \{Brasilino de Carvalho\}, Marcos and \{Mendonza L{\'o}pez\}, \{Rossana Ver{\'o}nica\} and Victor Wunsch-Filho and Paolo Boffetta and Mia Hashibe and \{Amy Lee\}, Yuan-Chin and Stefania Boccia",

note = "AJCR Copyright {\textcopyright} 2024.",

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month = nov,

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doi = "10.62347/UUXK7608",

language = "English",

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Pastorino, R, Pires Marafon, D, Lentini, N, Hoxhaj, I, Grossi, A, Giraldi, L, Rondinò, A, Cadoni, G, Polesel, J, Serraino, D, La Vecchia, C, Garavello, W, Canova, C, Richiardi, L, Lissowska, J, Pandics, T, Dudding, T, Ness, A, Thomas, S, Pring, M, Kelsey, K, McClean, M, Bradshaw, P, Zhang, Z-F, Morgenstern, H, Rozek, L, Wolf, G, Olshan, A, Liu, G, Hung, R, Vilensky, M, Brasilino de Carvalho, M, Mendonza López, RV, Wunsch-Filho, V, Boffetta, P, Hashibe, M, Amy Lee, Y-C & Boccia, S 2024, 'The effect of body mass index at diagnosis on survival of patients with squamous cell head and neck carcinoma', American Journal of Cancer Research, vol. 14, no. 11, pp. 5411-5426. https://doi.org/10.62347/UUXK7608

TY - JOUR

T1 - The effect of body mass index at diagnosis on survival of patients with squamous cell head and neck carcinoma

AU - Pastorino, Roberta

AU - Pires Marafon, Denise

AU - Lentini, Nicolò

AU - Hoxhaj, Ilda

AU - Grossi, Adriano

AU - Giraldi, Luca

AU - Rondinò, Antonella

AU - Cadoni, Gabriella

AU - Polesel, Jerry

AU - Serraino, Diego

AU - La Vecchia, Carlo

AU - Garavello, Werner

AU - Canova, Cristina

AU - Richiardi, Lorenzo

AU - Lissowska, Jolanta

AU - Pandics, Tamas

AU - Dudding, Tom

AU - Ness, Andy

AU - Thomas, Steve

AU - Pring, Miranda

AU - Kelsey, Karl

AU - McClean, Michael

AU - Bradshaw, Patrick

AU - Zhang, Zuo-Feng

AU - Morgenstern, Hal

AU - Rozek, Laura

AU - Wolf, Gregory

AU - Olshan, Andrew

AU - Liu, Geoffrey

AU - Hung, Rayjean

AU - Vilensky, Marta

AU - Brasilino de Carvalho, Marcos

AU - Mendonza López, Rossana Verónica

AU - Wunsch-Filho, Victor

AU - Boffetta, Paolo

AU - Hashibe, Mia

AU - Amy Lee, Yuan-Chin

AU - Boccia, Stefania

PY - 2024/11/30

Y1 - 2024/11/30

N2 - The aim of this study is to investigate the prognostic role of body mass index (BMI) on survival from head and neck cancer (HNC). We performed a pooled analysis of studies included in the International Head and Neck Cancer Epidemiology consortium. We used Cox proportional hazards models to estimate the adjusted hazard ratios (HR) for overall survival and HNC-specific survival, and we stratified the results according to cancer site. The study included 10,177 patients from 10 studies worldwide. Underweight patients had lower overall survival (HR=1.69, 95% CI: 1.31-2.19) respect to those having normal weight with consistent results across the HNC sites. Overweight and obese patients had a favourable HNC-specific survival (HR=0.77 (95% CI: 0.70-0.84) and HR=0.80 (95% CI: 0.76-0.84), respectively), with heterogenous results according to HNC site. Our findings show that high BMI values at cancer diagnosis improved the survival rates in patients with HNC, especially among smokers. This association may be explained by residual confounding, reverse causation, and collider stratification bias, but may also suggest that a nutritional reserve may help patients survive HNC cancer.

AB - The aim of this study is to investigate the prognostic role of body mass index (BMI) on survival from head and neck cancer (HNC). We performed a pooled analysis of studies included in the International Head and Neck Cancer Epidemiology consortium. We used Cox proportional hazards models to estimate the adjusted hazard ratios (HR) for overall survival and HNC-specific survival, and we stratified the results according to cancer site. The study included 10,177 patients from 10 studies worldwide. Underweight patients had lower overall survival (HR=1.69, 95% CI: 1.31-2.19) respect to those having normal weight with consistent results across the HNC sites. Overweight and obese patients had a favourable HNC-specific survival (HR=0.77 (95% CI: 0.70-0.84) and HR=0.80 (95% CI: 0.76-0.84), respectively), with heterogenous results according to HNC site. Our findings show that high BMI values at cancer diagnosis improved the survival rates in patients with HNC, especially among smokers. This association may be explained by residual confounding, reverse causation, and collider stratification bias, but may also suggest that a nutritional reserve may help patients survive HNC cancer.

U2 - 10.62347/UUXK7608

DO - 10.62347/UUXK7608

M3 - Article (Academic Journal)

C2 - 39659941

SN - 2156-6976

VL - 14

SP - 5411

EP - 5426

JO - American Journal of Cancer Research

JF - American Journal of Cancer Research

IS - 11

ER -

The effect of body mass index at diagnosis on survival of patients with squamous cell head and neck carcinoma

Abstract

Bibliographical note

UN SDGs

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