The effect of longer-term and exclusive breastfeeding promotion on visual outcome in adolescence

Christopher G Owen, Emily Oken, Alicja R Rudnicka, Rita Patel, Jennifer Thompson, Sheryl L Rifas-Shiman, Konstatin Vilchuck, Natalia Bogdanovich, Mikhail Hameza, Michael S. Kramer, Richard Martin

Research output: Contribution to journalArticle (Academic Journal)peer-review

4 Citations (Scopus)
170 Downloads (Pure)

Abstract

Purpose: Breastfeeding may influence early visual development. We examined whether an intervention to promote increased duration and exclusivity of breastfeeding improves visual outcomes at 16 years of age.
Methods: Follow-up of a cluster-randomized trial in 31 Belarusian maternity hospitals/polyclinics randomized to receive a breastfeeding promotion intervention, or usual care, where 46% vs 3% were exclusively breastfed at 3 months respectively. Low vision in either eye was defined as unaided LogMAR vision of 0.3 or worse (equivalent to Snellen 20/40) and was used as the primary outcome. Open-field autorefraction in a sub-set (N=963) suggested that 90% of those with low vision were myopic. Primary analysis was based on modified intention-to-treat, accounting for clustering within hospitals/clinics. Observational analyses examined other sociodemographic and environmental determinants of low vision.
Results: 13392 (79%) of 17046 participants were followed up at 16 years. Low vision prevalence was 24.2% (95%CI 21.6,26.9%) in the experimental group vs 25.4% (22.9,28.1%) in the control group. Cluster-adjusted odds ratio (OR) of low vision associated with the intervention was 0.95 (95%CI 0.75,1.19); 0.91 (95%CI 0.78,1.06) after adjustment for parental and early life factors. In observational analyses, higher parental education, maternal age at birth (OR 1.13, 95% CI 1.07,1.19/5 year increase), and urban vs rural residence were associated with increased risk of low vision. Number of older siblings was associated with a lower risk; boys had lower risks than girls (0.65, 95%CI 0.60,0.70).
Conclusions: Exclusive breastfeeding promotion had no significant effect on visual outcomes, but other environmental factors showed strong associations.
Original languageEnglish
Pages (from-to)2670-2678
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Volume59
Issue number7
DOIs
Publication statusPublished - 1 Jun 2018

Keywords

  • Breastfeeding
  • Childhood
  • Presumed myopia
  • Vision

Fingerprint Dive into the research topics of 'The effect of longer-term and exclusive breastfeeding promotion on visual outcome in adolescence'. Together they form a unique fingerprint.

Cite this