The effect of mate tea (Ilex paraguariensis) on metabolic and inflammatory parameters in high-fat diet-fed Wistar rats

Maria Carolina Borges, Marco Aurélio Ramirez Vinolo, Karina Nakajima, Inar Alves de Castro, Deborah Helena Markowicz Bastos, Primavera Borelli, Ricardo Ambrósio Fock, Julio Tirapegui, Rui Curi, Marcelo Macedo Rogero

Research output: Contribution to journalArticle (Academic Journal)peer-review

21 Citations (Scopus)


This study investigated the effects of mate tea (Ilex paraguariensis) aqueous extract consumption on metabolic indicators and inflammatory response of peritoneal macrophages in rats fed a high-fat diet (HFD). Male Wistar rats were fed a control diet or a HFD for 12 weeks. At the end of this period, rats received, or not, daily doses of yerba maté for 4 weeks. The consumption of yerba maté promoted weight loss, attenuated the HFD-detrimental effects on adiposity and insulin sensitivity and decreased blood levels of the inflammatory biomarkers (p < 0.05). Concerning peritoneal macrophages, mate tea consumption decreased the production of interleukin (IL)-6, but did not influence the production of IL-1β, tumour necrosis factor-α and nitric oxide; cytokine mRNA expression; or the activation of the nuclear factor-κB signalling pathway. In summary, the consumption of mate tea had no consistent effect in the inflammatory response of peritoneal macrophages, but reduced cardiometabolic risk markers.

Original languageEnglish
Pages (from-to)561-9
Number of pages9
JournalInternational Journal of Food Science and Technology
Issue number5
Publication statusPublished - Aug 2013


  • Adiposity
  • Animals
  • Biomarkers
  • Cardiovascular Diseases
  • Cytokines
  • Diet, High-Fat
  • Ilex paraguariensis
  • Inflammation
  • Inflammation Mediators
  • Insulin Resistance
  • Interleukin-6
  • Macrophages, Peritoneal
  • NF-kappa B
  • Nitric Oxide
  • Obesity
  • Phytotherapy
  • Plant Extracts
  • Rats
  • Rats, Wistar
  • Signal Transduction
  • Tumor Necrosis Factor-alpha
  • Weight Loss


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