The effect of nicotine on striatal dopamine release in man: A [11C]raclopride PET study

AJ Montgomery, AR Lingford-Hughes, A Egerton, DJ Nutt, PM Grasby

Research output: Contribution to journalArticle (Academic Journal)peer-review

79 Citations (Scopus)


In common with many addictive substances and behaviors nicotine activates the mesolimbic dopaminergic system. Brain microdialysis studies in rodents have consistently shown increases in extrasynaptic DA levels in the striatum after administration of nicotine but PET experiments in primates have given contradicting results. A recent PET study assessing the effect of smoking in humans showed no change in [11C]raclopride binding in the brain, but did find that hedonia correlated with a reduction in [11C]raclopride binding suggesting that DA may mediate the positive reinforcing effects of nicotine. In this experiment we measured the effect of nicotine, administered via a nasal spray, on DA release using [11C]raclopride PET, in 10 regular smokers. There was no overall change in [11C]raclopride binding after nicotine administration in any of the striatal regions examined. However, the individual change in [11C]raclopride binding correlated with change in subjective measures of amused and happiness in the associative striatum (AST) and sensorimotor striatum (SMST). Nicotine concentration correlated negatively with change in BP in the limbic striatum. Nicotine had significant effects on cardiovascular measures including pulse rate, systolic blood pressure (BPr), and diastolic BPr. Baseline [11C]raclopride binding potential (BP) in the AST correlated negatively with the Fagerström score, an index of nicotine dependence. These results support a role for the DA system in nicotine addiction, but reveal a more complex relationship than suggested by studies in animals.
Translated title of the contributionThe effect of nicotine on striatal dopamine release in man: A [11C]raclopride PET study
Original languageEnglish
Pages (from-to)637 - 645
Number of pages9
Volume61 (8)
Publication statusPublished - Aug 2007

Bibliographical note

Publisher: Wiley


Dive into the research topics of 'The effect of nicotine on striatal dopamine release in man: A [11C]raclopride PET study'. Together they form a unique fingerprint.

Cite this