The effect of omega-3 polyunsaturated fatty acids on the inflammatory response of the amnion

Lorraine Frew, N. U. Sugiarto, Shalini P. Rajagopal, J. He, Rosemary Leask, Jane E. Norman, Simon C. Riley, Sarah J. Stock

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

ObjectiveTo investigate the effect of omega-3 PUFAs, eicosapentanoic acid (EPA) and docosohexanoic acid (DHA) on inflammatory cytokine production in the amnion.Study designAmnion explants were obtained at elective caesarean sections and cultured in vitro with EPA and DHA. IL-8 and IL-6 secretion was determined by ELISA, the role of PPARγ was investigated using specific agonists and antagonists and activity of MMP assessed by gelatin zymography.ResultsA combination of EPA and DHA significantly reduced the concentration of IL-8 and IL-6 released into the supernatant compared to untreated controls (p
Original languageEnglish
Pages (from-to)221-225
Number of pages5
JournalProstaglandins, Leukotrienes, and Essential Fatty Acids
Volume89
Issue number4
DOIs
Publication statusPublished - 2013

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