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The effect of resuscitation in 100% oxygen on brain injury in a newborn rat model of severe hypoxic-ischaemic encephalopathy

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)214-9
Number of pages6
JournalResuscitation
Volume96
Early online date21 Aug 2015
DOIs
DateAccepted/In press - 30 Jul 2015
DateE-pub ahead of print - 21 Aug 2015
DatePublished (current) - 1 Nov 2015

Abstract

AIM: Infants with birth asphyxia frequently require resuscitation. Current guidance is to start newborn resuscitation in 21% oxygen. However, infants with severe hypoxia-ischaemia may require prolonged resuscitation with oxygen. To date, no study has looked at the effect of resuscitation in 100% oxygen following a severe hypoxic-ischaemic insult.

METHODS: Postnatal day 7 Wistar rats underwent a severe hypoxic-ischaemic insult (modified Vannucci unilateral brain injury model) followed by immediate resuscitation in either 21% or 100% oxygen for 30min. Seven days following the insult, negative geotaxis testing was performed in survivors, and the brains were harvested. Relative ipsilateral cortical and hippocampal area loss was assessed histologically.

RESULTS: Total area loss in the affected hemisphere and area loss within the hippocampus did not significantly differ between the two groups. The same results were seen for short-term neurological assessment. No difference was seen in weight gain between pups resuscitated in 21% and 100% oxygen.

CONCLUSION: Resuscitation in 100% oxygen does not cause a deleterious effect on brain injury following a severe hypoxic-ischaemic insult in a rat model of hypoxia-ischaemia. Further work investigating the effects of resuscitation in 100% oxygen is warranted, especially for newborn infants with severe hypoxic-ischaemic encephalopathy.

    Research areas

  • Hyperoxia, Oxidative stress, Asphyxia, Rat model, Newborn resuscitation

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  • Smit E. Resus with 100% oxygen

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at http://dx.doi.org/10.1016/j.resuscitation.2015.07.050. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 370 KB, PDF document

    Licence: CC BY-NC-ND

  • Elisa Figure 1 Resus 100% oxygen

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at http://dx.doi.org/10.1016/j.resuscitation.2015.07.050. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 98 KB, PDF document

    Licence: CC BY-NC-ND

  • Elisa_Figures_2-4_Resus_100_oxygen

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at http://dx.doi.org/10.1016/j.resuscitation.2015.07.050. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 322 KB, PDF document

    Licence: CC BY-NC-ND

  • Smit E. Resus with 100% oxygen. Table 1 revised manuscript

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at http://dx.doi.org/10.1016/j.resuscitation.2015.07.050. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 174 KB, PDF document

    Licence: CC BY-NC-ND

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