The effectiveness and efficacy of Rhodiola rosea L. a systematic review of randomized clinical trials

Shao Kang Hung*, Rachel Perry, Edzard Ernst

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

74 Citations (Scopus)

Abstract

OBJECTIVE: To critically assess the current evidence from randomized clinical trials (RCTs) for or against the effectiveness or efficacy of Rhodiola rosea.

DATA SOURCES: Systematic literature searches were performed in six electronic databases: AMED (1985-July 2009), CINAHL (1982-July 2009), The Cochrane Library (search in July 2009), EMBASE (1974-July 2009), MEDLINE (1950-July 2009) and Web of Science (searched in July 2009). No language restrictions were imposed. Reference lists of all retrieved articles were searched, and experts and manufacturers were contacted for unpublished RCT.

REVIEW METHODS: RCTs testing the efficacy or effectiveness of mono-preparations of R. rosea as sole treatment administered orally against a control intervention in any human individual suffering from any condition or healthy human volunteers were included. Studies were selected, data extracted, and quality assessed by two independent reviewers.

RESULTS: Eleven RCTs met the inclusion criteria; all were placebo-controlled. Six trials investigated the effects of R. rosea on physical performance, four on mental performance, and two in patients diagnosed with mental health condition. The methodological quality of most trials was moderate or good. Only few mild adverse events were reported.

CONCLUSION: R. rosea may have beneficial effects on physical performance, mental performance, and certain mental health conditions. There is, however, a lack of independent replications of the single different studies. Five of the 10 RCTs reached more than three points on the Jadad score (i.e., good quality). More research seems warranted.

Original languageEnglish
Pages (from-to)235-244
Number of pages10
JournalPhytomedicine
Volume18
Issue number4
DOIs
Publication statusPublished - 15 Feb 2011

Keywords

  • Rhodiola rosea
  • Physical and mental performance
  • Randomized clinical trials
  • Jadad score
  • STANDARDIZED EXTRACT SHR-5
  • LOW-DOSE REGIMEN
  • DOUBLE-BLIND
  • PUBLICATION BIAS
  • STRESS
  • FATIGUE
  • PLACEBO
  • SUPPLEMENTATION
  • PERFORMANCE
  • ROOTS

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