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Abstract
Background: Green tea or green tea extract (GT/GTE) has been demonstrated to reduce insulin resistance and improve glycaemic control. However, evidence for this health beneficial effect is inconsistent. This systematic review evaluated the effect of GT/GTE on insulin resistance and glycaemic control in people with pre-diabetes/type 2 diabetes mellitus (T2DM).
Methods: Ovid MEDLINE, Embase, AMED, Web of Science and the Cochrane library were searched up to April 2017 for Randomised Controlled Trials of participants with pre-diabetes or type 2 diabetes, where the intervention was GT/GTE. Meta-analysis was performed to assess the standardised mean difference (SMD) in biomarkers of insulin resistance and glycaemic control between GT/GTE and placebo groups.
Results: Six studies (n= 382) were pooled into random-effects meta-analysis. Overall, no differences were found between GT/GTE and the placebo for HbA1c (SMD -0.32; 95%CI -0.86, 0.23), HOMA-IR (SMD 0.10; 95%CI -0.17, 0.38), fasting insulin (SMD -0.25; 95%CI -0.64, 0.15), and fasting glucose (SMD -0.10; 95%CI -0.50, 0.3).
Conclusions: No evidence support the consumption of GT/GTE could reduce the levels of HbA1c, HOMA-IR, fasting insulin or fasting glucose in people with pre-diabetes/T2DM. However, the studies included were small and of varying quality.
Methods: Ovid MEDLINE, Embase, AMED, Web of Science and the Cochrane library were searched up to April 2017 for Randomised Controlled Trials of participants with pre-diabetes or type 2 diabetes, where the intervention was GT/GTE. Meta-analysis was performed to assess the standardised mean difference (SMD) in biomarkers of insulin resistance and glycaemic control between GT/GTE and placebo groups.
Results: Six studies (n= 382) were pooled into random-effects meta-analysis. Overall, no differences were found between GT/GTE and the placebo for HbA1c (SMD -0.32; 95%CI -0.86, 0.23), HOMA-IR (SMD 0.10; 95%CI -0.17, 0.38), fasting insulin (SMD -0.25; 95%CI -0.64, 0.15), and fasting glucose (SMD -0.10; 95%CI -0.50, 0.3).
Conclusions: No evidence support the consumption of GT/GTE could reduce the levels of HbA1c, HOMA-IR, fasting insulin or fasting glucose in people with pre-diabetes/T2DM. However, the studies included were small and of varying quality.
| Original language | English |
|---|---|
| Pages (from-to) | 251-262 |
| Number of pages | 12 |
| Journal | Diabetes and Metabolism Journal |
| Volume | 41 |
| Issue number | 4 |
| Early online date | 22 Aug 2017 |
| DOIs | |
| Publication status | Published - Aug 2017 |
Keywords
- Green tea
- Type 2 Diabetes
- Meta-Analysis
- Glycaemic control
- Insulin resistance
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