The effectiveness of low dead space syringes for reducing the risk of hepatitis C virus acquisition among people who inject drugs: findings from a national survey in England, Wales, and Northern Ireland

Adam J W Trickey; Sara Croxford; Eva Emanuel; Samreen Ijaz; Matt  Hickman; Joanna  Kesten; Clare L Thomas; C. Edmundson; Monica Desai; Peter T Vickerman

doi:10.1093/cid/ciac140

The effectiveness of low dead space syringes for reducing the risk of hepatitis C virus acquisition among people who inject drugs: findings from a national survey in England, Wales, and Northern Ireland

Adam J W Trickey^*, Sara Croxford, Eva Emanuel, Samreen Ijaz, Matt Hickman, Joanna Kesten, Clare L Thomas, C. Edmundson, Monica Desai, Peter T Vickerman

^*Corresponding author for this work

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Abstract

Syringes with attached needles (termed fixed low dead space syringes [LDSS]) retain less blood following injection than syringes with detachable needles, but evidence on them reducing blood borne virus transmission among people who inject drugs (PWID) is lacking. Utilising the UK Unlinked Anonymous Monitoring cross-sectional bio-behavioural surveys among PWID for 2016/18/19 (n=1429), we showed that always using fixed LDSS was associated with 76% lower likelihood (adjusted Odds Ratio=0.24, 95%CI: 0.08-0.67) of recent hepatitis C virus infection (RNA-positive and antibody-negative) among antibody-negative PWID compared to using any syringes with detachable needles.

Original language	English
Article number	ciac140
Pages (from-to)	1073-1077
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	75
Issue number	6
Early online date	20 Feb 2022
DOIs	https://doi.org/10.1093/cid/ciac140
Publication status	Published - 15 Sept 2022

Bibliographical note

Publisher Copyright:
© The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America.

Keywords

Low dead space syringes
high dead space syringes
injecting drugs
IDU
HCV

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Trickey, A. J. W., Croxford, S., Emanuel, E., Ijaz, S., Hickman, M., Kesten, J., Thomas, C. L., Edmundson, C., Desai, M., & Vickerman, P. T. (2022). The effectiveness of low dead space syringes for reducing the risk of hepatitis C virus acquisition among people who inject drugs: findings from a national survey in England, Wales, and Northern Ireland. Clinical Infectious Diseases, 75(6), 1073-1077. Article ciac140. https://doi.org/10.1093/cid/ciac140

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title = "The effectiveness of low dead space syringes for reducing the risk of hepatitis C virus acquisition among people who inject drugs: findings from a national survey in England, Wales, and Northern Ireland",

abstract = "Syringes with attached needles (termed fixed low dead space syringes [LDSS]) retain less blood following injection than syringes with detachable needles, but evidence on them reducing blood borne virus transmission among people who inject drugs (PWID) is lacking. Utilising the UK Unlinked Anonymous Monitoring cross-sectional bio-behavioural surveys among PWID for 2016/18/19 (n=1429), we showed that always using fixed LDSS was associated with 76% lower likelihood (adjusted Odds Ratio=0.24, 95%CI: 0.08-0.67) of recent hepatitis C virus infection (RNA-positive and antibody-negative) among antibody-negative PWID compared to using any syringes with detachable needles.",

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author = "Trickey, {Adam J W} and Sara Croxford and Eva Emanuel and Samreen Ijaz and Matt Hickman and Joanna Kesten and Thomas, {Clare L} and C. Edmundson and Monica Desai and Vickerman, {Peter T}",

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Trickey, AJW, Croxford, S, Emanuel, E, Ijaz, S, Hickman, M , Kesten, J , Thomas, CL, Edmundson, C, Desai, M & Vickerman, PT 2022, 'The effectiveness of low dead space syringes for reducing the risk of hepatitis C virus acquisition among people who inject drugs: findings from a national survey in England, Wales, and Northern Ireland', Clinical Infectious Diseases, vol. 75, no. 6, ciac140, pp. 1073-1077. https://doi.org/10.1093/cid/ciac140

The effectiveness of low dead space syringes for reducing the risk of hepatitis C virus acquisition among people who inject drugs: findings from a national survey in England, Wales, and Northern Ireland. / Trickey, Adam J W; Croxford, Sara; Emanuel, Eva et al.
In: Clinical Infectious Diseases, Vol. 75, No. 6, ciac140, 15.09.2022, p. 1073-1077.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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AU - Trickey, Adam J W

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AU - Vickerman, Peter T

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AB - Syringes with attached needles (termed fixed low dead space syringes [LDSS]) retain less blood following injection than syringes with detachable needles, but evidence on them reducing blood borne virus transmission among people who inject drugs (PWID) is lacking. Utilising the UK Unlinked Anonymous Monitoring cross-sectional bio-behavioural surveys among PWID for 2016/18/19 (n=1429), we showed that always using fixed LDSS was associated with 76% lower likelihood (adjusted Odds Ratio=0.24, 95%CI: 0.08-0.67) of recent hepatitis C virus infection (RNA-positive and antibody-negative) among antibody-negative PWID compared to using any syringes with detachable needles.

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KW - high dead space syringes

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KW - IDU

KW - HCV

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Trickey AJW, Croxford S, Emanuel E, Ijaz S, Hickman M , Kesten J et al. The effectiveness of low dead space syringes for reducing the risk of hepatitis C virus acquisition among people who inject drugs: findings from a national survey in England, Wales, and Northern Ireland. Clinical Infectious Diseases. 2022 Sept 15;75(6):1073-1077. ciac140. Epub 2022 Feb 20. doi: 10.1093/cid/ciac140

The effectiveness of low dead space syringes for reducing the risk of hepatitis C virus acquisition among people who inject drugs: findings from a national survey in England, Wales, and Northern Ireland

Abstract

Bibliographical note

Keywords

UN SDGs

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