The effects of a chronic infusion of arginine vasopressin in salt-restricted, water-deprived man

P J Drew, J N Barnes, J M Holly, A Knight, F J Goodwin

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)

Abstract

The effects of a 48 h infusion of arginine vasopressin (AVP) were measured in five separate studies on four normal salt-restricted physicians, in whom fluid retention was prevented. The infusion was associated with an increase in renal sodium excretion which continued during the 24 h after the infusion had been discontinued. During the infusion plasma renin activity (PRA), plasma aldosterone and noradrenaline, and packed cell volume (PCV) fell; glomerular filtration rate, assessed by endogenous creatinine clearance, increased. The findings are best explained by a vasopressin-induced increase in plasma volume, which in the absence of fluid retention is likely to have been due to a redistribution of body water.
Original languageEnglish
Pages (from-to)353-8
Number of pages6
JournalClinical Science
Volume67
Issue number3
Publication statusPublished - 1984

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