The effects of acute pharmacological stimulation of the 5-HT, NA and DA systems on the cognitive judgement bias of rats in the ambiguous-cue interpretation paradigm

Rafal Rygula*, Justyna Papciak, Piotr Popik

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

37 Citations (Scopus)

Abstract

In the present study, we investigated the effects of acute pharmacological stimulation of the serotonergic (5-HT), noradrenergic (NA) and dopaminergic (DA) systems on the valence of cognitive judgement bias of rats in the ambiguous-cue interpretation (ACI) paradigm. To accomplish this goal, after initial behavioural training, different groups of rats received single injections of citalopram, desipramine or d-amphetamine and were subsequently tested with the ACI paradigm. Each drug was administered in 3 doses using a fully randomised Latin square design. Citalopram at the dose of 1mg/kg significantly biased animals towards positive interpretation of the ambiguous cue, while at higher doses (5 and 10mg/kg), the animals interpreted the ambiguous cue more negatively. Desipramine at all 3 tested doses (1, 2 and 5mg/kg) significantly biased animals towards negative interpretation of the ambiguous cue, while d-amphetamine at the dose of 1mg/kg induced positive bias, having no effects at lower doses (0.1 and 0.5mg/kg). Our results indicate that cognitive bias in rats can be influenced by acute pharmacological intervention.

Original languageEnglish
Pages (from-to)1103-1111
Number of pages9
JournalEuropean Neuropsychopharmacology
Volume24
Issue number7
Early online date18 Jan 2014
DOIs
Publication statusPublished - 1 Jul 2014

Keywords

  • Ambiguous-cue
  • Citalopram
  • Desipramine
  • Cognitive bias
  • d-Amphetamine
  • Rat

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