TY - JOUR
T1 - The effects of cocaine and mazindol on the cognitive judgement bias of rats in the ambiguous-cue interpretation paradigm
AU - Rygula, Rafal
AU - Szczech, Ewa
AU - Papciak, Justyna
AU - Nikiforuk, Agnieszka
AU - Popik, Piotr
N1 - Copyright © 2014 Elsevier B.V. All rights reserved.
PY - 2014/8/15
Y1 - 2014/8/15
N2 - Recent research has shown that pharmacological enhancement of dopaminergic function increases an optimism bias in humans. The present study investigated whether acute dopaminergic system stimulation through the administration of two dopamine-mimetic drugs, cocaine and mazindol, have similar effects in rats. To accomplish this goal, after initial behavioural training, two groups of rats received single injections of either cocaine or mazindol and were subsequently tested with the ambiguous-cue interpretation (ACI) paradigm. Both drugs were administered in three doses using the fully randomised Latin square designs. Cocaine (1, 2 and 5mg/kg) had no significant effect on the interpretation of the ambiguous cue. Mazindol at all three doses (0.5, 1 and 2mg/kg) significantly biased animals towards negative interpretation of the ambiguous cue. The results are discussed in relation to pharmacological and behaviourally evoked actions of tested compounds.
AB - Recent research has shown that pharmacological enhancement of dopaminergic function increases an optimism bias in humans. The present study investigated whether acute dopaminergic system stimulation through the administration of two dopamine-mimetic drugs, cocaine and mazindol, have similar effects in rats. To accomplish this goal, after initial behavioural training, two groups of rats received single injections of either cocaine or mazindol and were subsequently tested with the ambiguous-cue interpretation (ACI) paradigm. Both drugs were administered in three doses using the fully randomised Latin square designs. Cocaine (1, 2 and 5mg/kg) had no significant effect on the interpretation of the ambiguous cue. Mazindol at all three doses (0.5, 1 and 2mg/kg) significantly biased animals towards negative interpretation of the ambiguous cue. The results are discussed in relation to pharmacological and behaviourally evoked actions of tested compounds.
KW - Ambiguous-cue
KW - Cocaine
KW - Cognitive bias
KW - Mazindol
KW - Rat
U2 - 10.1016/j.bbr.2014.05.026
DO - 10.1016/j.bbr.2014.05.026
M3 - Article (Academic Journal)
C2 - 24859175
VL - 270
SP - 206
EP - 212
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
ER -