Abstract
ABSTRACT
Background: Isoflavone phytoestrogen therapy has been proposed
as a natural alternative to hormone replacement therapy
(HRT). HRT has a beneficial effect on bone, but few trials in
humans have investigated the effects of isoflavones on bone.
Objective: The objective of the study was to determine the effect
on bone density of a red clover–derived isoflavone supplement that
provided a daily dose of 26 mg biochanin A, 16 mg formononetin,
1 mg genistein, and 0.5 mg daidzein for 1 y. Effects on biochemical
markers of bone turnover and body composition were also
studied.
Design: Women aged 49–65 y (n 205) were enrolled in a
double-blind, randomized, placebo-controlled trial; 177 completed
the trial. Bone density, body composition, bone turnover markers,
and diet were measured at baseline and after 12 mo.
Results: Loss of lumbar spine bone mineral content and bone
mineral density was significantly (P 0.04 and P 0.03, respectively)
lower in the women taking the isoflavone supplement than
in those taking the placebo. There were no significant treatment
effects on hip bone mineral content or bone mineral density,
markers of bone resorption, or body composition, but bone formation
markers were significantly increased (P 0.04 and P 0.01
for bone-specific alkaline phosphatase and N-propeptide of collagen
type I, respectively) in the intervention group compared with
placebo in postmenopausal women. Interactions between treatment
group and menopausal status with respect to changes in other
outcomes were not significant.
Conclusion: These data suggest that, through attenuation of bone
loss, isoflavones have a potentially protective effect on the lumbar
spine in women. Am J Clin Nutr 2004;79:326–33.
Translated title of the contribution | The Effects of Phytoestrogen Isoflavones on Bone Density in Women: a Double-Blind, Randomized, Placebo-Controlled Trial |
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Original language | English |
Pages (from-to) | 326 - 333 |
Number of pages | 8 |
Journal | American Journal of Clinical Nutrition |
Volume | 79 (2) |
Publication status | Published - Feb 2004 |