The Effects of Xenon Gas Inhalation on Neuropathology in a Placental-Induced Brain Injury Model in Neonates: A Pilot Study

Thomas Phillips, David A Menassa, Simon Grant, Nicki Cohen, Marianne Thoresen*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

32 Downloads (Pure)

Abstract

Improved obstetric and neonatal care have reduced the prevalence of severe hypoxic‐ischemic‐encephalopathy (HIE), however 1‐3/1000 newborns in the developed world(1) suffer death or neurodevelopmental disability from HIE. The normal development of the brain during gestation can also be altered by placental reprogramming under oxidative stress. Under these conditions, the placenta releases DNA damaging molecules, bone morphogenic proteins, microRNAs, and glutamate(2). At present, one is unable to diagnose or treat these factors.
Original languageEnglish
Number of pages4
JournalActa Paediatrica
Early online date18 Jul 2020
DOIs
Publication statusPublished - 3 Aug 2020

Keywords

  • Xenon
  • hypoxic-ischaemic encephalopathy
  • brain injury
  • neurodevelopment
  • cooling
  • placental reprogramming

Fingerprint

Dive into the research topics of 'The Effects of Xenon Gas Inhalation on Neuropathology in a Placental-Induced Brain Injury Model in Neonates: A Pilot Study'. Together they form a unique fingerprint.

Cite this