The Effects of Xenon Gas Inhalation on Neuropathology in a Placental-Induced Brain Injury Model in Neonates: A Pilot Study

Thomas Phillips; David A Menassa; Simon  Grant; Nicki Cohen; Marianne Thoresen

doi:10.1111/apa.15486

The Effects of Xenon Gas Inhalation on Neuropathology in a Placental-Induced Brain Injury Model in Neonates: A Pilot Study

Thomas Phillips, David A Menassa, Simon Grant, Nicki Cohen, Marianne Thoresen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Improved obstetric and neonatal care have reduced the prevalence of severe hypoxic‐ischemic‐encephalopathy (HIE), however 1‐3/1000 newborns in the developed world(1) suffer death or neurodevelopmental disability from HIE. The normal development of the brain during gestation can also be altered by placental reprogramming under oxidative stress. Under these conditions, the placenta releases DNA damaging molecules, bone morphogenic proteins, microRNAs, and glutamate(2). At present, one is unable to diagnose or treat these factors.

Original language	English
Number of pages	4
Journal	Acta Paediatrica
Early online date	18 Jul 2020
DOIs	https://doi.org/10.1111/apa.15486
Publication status	Published - 3 Aug 2020

Keywords

Xenon
hypoxic-ischaemic encephalopathy
brain injury
neurodevelopment
cooling
placental reprogramming

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title = "The Effects of Xenon Gas Inhalation on Neuropathology in a Placental-Induced Brain Injury Model in Neonates: A Pilot Study",

abstract = "Improved obstetric and neonatal care have reduced the prevalence of severe hypoxic‐ischemic‐encephalopathy (HIE), however 1‐3/1000 newborns in the developed world(1) suffer death or neurodevelopmental disability from HIE. The normal development of the brain during gestation can also be altered by placental reprogramming under oxidative stress. Under these conditions, the placenta releases DNA damaging molecules, bone morphogenic proteins, microRNAs, and glutamate(2). At present, one is unable to diagnose or treat these factors.",

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AU - Phillips, Thomas

AU - Menassa, David A

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AU - Cohen, Nicki

AU - Thoresen, Marianne

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AB - Improved obstetric and neonatal care have reduced the prevalence of severe hypoxic‐ischemic‐encephalopathy (HIE), however 1‐3/1000 newborns in the developed world(1) suffer death or neurodevelopmental disability from HIE. The normal development of the brain during gestation can also be altered by placental reprogramming under oxidative stress. Under these conditions, the placenta releases DNA damaging molecules, bone morphogenic proteins, microRNAs, and glutamate(2). At present, one is unable to diagnose or treat these factors.

KW - Xenon

KW - hypoxic-ischaemic encephalopathy

KW - brain injury

KW - neurodevelopment

KW - cooling

KW - placental reprogramming

U2 - 10.1111/apa.15486

DO - 10.1111/apa.15486

M3 - Article (Academic Journal)

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JO - Acta Paediatrica

JF - Acta Paediatrica

ER -

The Effects of Xenon Gas Inhalation on Neuropathology in a Placental-Induced Brain Injury Model in Neonates: A Pilot Study

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