The Efficacy of Plasma Rich in Growth Factors for the Treatment of Alveolar Osteitis: A Randomized Controlled Trial

Elizabeth M. King, Tanya L. Cerajewska, Matthew Locke, Nicholas C.A. Claydon, Maria Davies, Nicola X. West*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)
325 Downloads (Pure)

Abstract

Purpose: To investigate the efficacy of plasma rich in growth factors (PRGF)® for the treatment of alveolar osteitis compared to a positive control Alvogyl®.

Methods: This single centre, single blind, randomised, two treatment, parallel study was conducted in a UK dental hospital. All healthy adults who presented with alveolar osteitis following tooth extraction over a 3 month period were invited to participate. Each socket was randomised and treated with one of two treatment modalities, a test treatment PRGF® or a positive control Alvogyl®. Following treatment, patients were reviewed at 3 and 7 days by a second clinician blinded to the treatment given. Outcome measures included pain, exposed bone, inflammation, halitosis, dysgeusia and quality of life assessment.

Results: 38 patients with data from 44 sockets, 22 in the PRGF® group and 22 in the Alvogyl® group, were analysed. The PRGF® group demonstrated significantly faster bone coverage as well as significantly reduced inflammation and halitosis (p<0.05) compared to the control group receiving Alvogyl®. There was no significant difference for pain, quality of life measures or dysgeusia between the groups.

Conclusion: PRGF® predictably treated alveolar osteitis following tooth extraction compared to the conventional standard treatment of Alvogyl® which has been used for many years. PRGF could be considered as an alternative treatment for alveolar osteitis, and indeed appears to have significant advantages over Alvogel®.

Original languageEnglish
Number of pages10
JournalJournal of Oral and Maxillofacial Surgery
Early online date8 Jan 2018
DOIs
Publication statusE-pub ahead of print - 8 Jan 2018

Keywords

  • alveolar osteitis
  • plasma rich in growth factors
  • alvogyl
  • bone healing
  • PRGF

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