The emerging role of retromer in neuroprotection

Kirsty J McMillan, Hendrick C Korswagen, Peter J Cullen

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)
290 Downloads (Pure)

Abstract

Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell–cell and cell–matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson’s disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson’s disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.
Original languageEnglish
Pages (from-to)72-82
Number of pages11
JournalCurrent Opinion in Cell Biology
Volume47
Early online date8 Apr 2017
DOIs
Publication statusPublished - Aug 2017

Bibliographical note

Special issue: SI: 47: Cell Organelles

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