Projects per year
Abstract
Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell–cell and cell–matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson’s disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson’s disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.
Original language | English |
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Pages (from-to) | 72-82 |
Number of pages | 11 |
Journal | Current Opinion in Cell Biology |
Volume | 47 |
Early online date | 8 Apr 2017 |
DOIs | |
Publication status | Published - Aug 2017 |
Bibliographical note
Special issue: SI: 47: Cell OrganellesFingerprint
Dive into the research topics of 'The emerging role of retromer in neuroprotection'. Together they form a unique fingerprint.Projects
- 1 Finished
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Analysing the cell biology of Parkinson's Disease-linked missense mutation in the retromer VPS35 subunit.
Cullen , P. J. (Principal Investigator)
1/10/13 → 30/09/16
Project: Research