Endocannabinoids in the midbrain periaqueductal grey (PAG) modulate nociception and unconditioned stress-induced analgesia; however, their role in fear-conditioned analgesia (FCA) has not been examined. The present study examined the role of the endocannabinoid system in the dorsolateral (dl) PAG in formalin-evoked nociceptive behaviour, conditioned fear and FCA in rats.
Bibliographical note© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.
- Cannabinoid Receptor Modulators
- Conditioning (Psychology)
- Motor Activity
- Periaqueductal Gray
- Receptor, Cannabinoid, CB1