The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone

W M Olango; M Roche; G K Ford; B Harhen; D P Finn

doi:10.1111/j.1476-5381.2011.01478.x

The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone

W M Olango, M Roche, G K Ford, B Harhen, D P Finn

Research output: Contribution to journal › Article (Academic Journal) › peer-review

60 Citations (Scopus)

Abstract

Endocannabinoids in the midbrain periaqueductal grey (PAG) modulate nociception and unconditioned stress-induced analgesia; however, their role in fear-conditioned analgesia (FCA) has not been examined. The present study examined the role of the endocannabinoid system in the dorsolateral (dl) PAG in formalin-evoked nociceptive behaviour, conditioned fear and FCA in rats.

Original language	English
Pages (from-to)	2549-60
Number of pages	12
Journal	British Journal of Pharmacology
Volume	165
Issue number	8
DOIs	https://doi.org/10.1111/j.1476-5381.2011.01478.x
Publication status	Published - Apr 2012

Bibliographical note

Keywords

Analgesia
Animals
Cannabinoid Receptor Modulators
Conditioning (Psychology)
Endocannabinoids
Fear
Formaldehyde
Male
Motor Activity
Pain
Periaqueductal Gray
Piperidines
Pyrazoles
Rats
Receptor, Cannabinoid, CB1
Ultrasonics

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title = "The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone",

abstract = "Endocannabinoids in the midbrain periaqueductal grey (PAG) modulate nociception and unconditioned stress-induced analgesia; however, their role in fear-conditioned analgesia (FCA) has not been examined. The present study examined the role of the endocannabinoid system in the dorsolateral (dl) PAG in formalin-evoked nociceptive behaviour, conditioned fear and FCA in rats.",

keywords = "Analgesia, Animals, Cannabinoid Receptor Modulators, Conditioning (Psychology), Endocannabinoids, Fear, Formaldehyde, Male, Motor Activity, Pain, Periaqueductal Gray, Piperidines, Pyrazoles, Rats, Receptor, Cannabinoid, CB1, Ultrasonics",

author = "Olango, {W M} and M Roche and Ford, {G K} and B Harhen and Finn, {D P}",

note = "{\textcopyright} 2011 The Authors. British Journal of Pharmacology {\textcopyright} 2011 The British Pharmacological Society.",

year = "2012",

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doi = "10.1111/j.1476-5381.2011.01478.x",

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volume = "165",

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journal = "British Journal of Pharmacology",

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The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone. / Olango, W M; Roche, M; Ford, G K et al.
In: British Journal of Pharmacology, Vol. 165, No. 8, 04.2012, p. 2549-60.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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AU - Roche, M

AU - Ford, G K

AU - Harhen, B

AU - Finn, D P

PY - 2012/4

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KW - Analgesia

KW - Animals

KW - Cannabinoid Receptor Modulators

KW - Conditioning (Psychology)

KW - Endocannabinoids

KW - Fear

KW - Formaldehyde

KW - Male

KW - Motor Activity

KW - Pain

KW - Periaqueductal Gray

KW - Piperidines

KW - Pyrazoles

KW - Rats

KW - Receptor, Cannabinoid, CB1

KW - Ultrasonics

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DO - 10.1111/j.1476-5381.2011.01478.x

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SN - 0007-1188

VL - 165

SP - 2549

EP - 2560

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 8

ER -

The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone

Abstract

Bibliographical note

Keywords

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