The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone

W M Olango, M Roche, G K Ford, B Harhen, D P Finn

Research output: Contribution to journalArticle (Academic Journal)peer-review

52 Citations (Scopus)

Abstract

Endocannabinoids in the midbrain periaqueductal grey (PAG) modulate nociception and unconditioned stress-induced analgesia; however, their role in fear-conditioned analgesia (FCA) has not been examined. The present study examined the role of the endocannabinoid system in the dorsolateral (dl) PAG in formalin-evoked nociceptive behaviour, conditioned fear and FCA in rats.
Original languageEnglish
Pages (from-to)2549-60
Number of pages12
JournalBritish Journal of Pharmacology
Volume165
Issue number8
DOIs
Publication statusPublished - Apr 2012

Bibliographical note

© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.

Keywords

  • Analgesia
  • Animals
  • Cannabinoid Receptor Modulators
  • Conditioning (Psychology)
  • Endocannabinoids
  • Fear
  • Formaldehyde
  • Male
  • Motor Activity
  • Pain
  • Periaqueductal Gray
  • Piperidines
  • Pyrazoles
  • Rats
  • Receptor, Cannabinoid, CB1
  • Ultrasonics

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