TY - JOUR
T1 - The Environmental Determinants of Diabetes in the Young (TEDDY) Study
T2 - 2018 Update
AU - TEDDY Study Group
AU - Hyöty, Heikki
AU - Rewers, Marian
AU - Lernmark, Åke
AU - Hagopian, William
AU - She, Jin-Xiong
AU - Schatz, Desmond
AU - Ziegler, Anette-G
AU - Toppari, Jorma
AU - Akolkar, Beena
AU - Krischer, Jeffrey
AU - Bingley, Polly
PY - 2018/10/23
Y1 - 2018/10/23
N2 - PURPOSE OF REVIEW: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D.RECENT FINDINGS: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed "omics" studies will provide novel information on the pathogenesis of T1D.
AB - PURPOSE OF REVIEW: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D.RECENT FINDINGS: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed "omics" studies will provide novel information on the pathogenesis of T1D.
U2 - 10.1007/s11892-018-1113-2
DO - 10.1007/s11892-018-1113-2
M3 - Review article (Academic Journal)
C2 - 30353256
SN - 1534-4827
VL - 18
SP - 136
JO - Current diabetes reports
JF - Current diabetes reports
IS - 12
ER -
