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The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update

Research output: Contribution to journalReview article

  • TEDDY Study Group
  • Heikki Hyöty
  • Marian Rewers
  • Åke Lernmark
  • William Hagopian
  • Jin-Xiong She
  • Desmond Schatz
  • Anette-G Ziegler
  • Jorma Toppari
  • Beena Akolkar
  • Jeffrey Krischer
Original languageEnglish
Pages (from-to)136
JournalCurrent diabetes reports
Volume18
Issue number12
DOIs
DateE-pub ahead of print - 23 Oct 2018

Abstract

PURPOSE OF REVIEW: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D.

RECENT FINDINGS: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed "omics" studies will provide novel information on the pathogenesis of T1D.

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