The erosion protection efficacy of a stabilized stannous fluoride dentifrice: An in situ randomized clinical trial

Nicola West, Nicola Hellin, Rachelle Eusebio, Tao He

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Purpose: To compare the enamel protection efficacy of a stabilized stannous fluoride dentifrice to a triclosan-containing sodium fluoride dentifrice using a 10-day in situ erosion model, in accordance with the American Dental Association Seal of Acceptance guidelines for enamel erosion control. 
Methods: In this single-center, double-blind, randomized, supervised-usage, 2-treatment, 4-period, crossover study, healthy adult subjects were randomized to a treatment sequence involving the following products: a 0.454% stannous fluoride (1100 ppm F) dentifrice (Procter & Gamble) and a control dentifrice containing 0.243% sodium fluoride (1100 ppm F) and 0.3% triclosan (NaF/triclosan, Colgate-Palmolive). Each study period consisted of 10 treatment days. Subjects wore an intra-oral appliance fitted with 2 polished human enamel samples for 6 hours per treatment day. While wearing the appliance, subjects swished with their assigned dentifrice slurry for 60 seconds twice daily and with 250 ml orange juice over a 10-minute period 4 times daily. After 10 days, enamel specimens were removed and measured for surface loss using contact profilometry. 
Results: Thirty-six subjects were enrolled and 33 completed the study (mean age = 41.8 years). The stannous fluoride dentifrice demonstrated 90.3% less enamel loss than the NaF/triclosan dentifrice (P < 0.001) at Day 10, with median enamel loss of 0.279 µm and 2.877 µm, respectively. Both products were well tolerated. 
Clinical Significance: The stannous fluoride dentifrice provided significantly greater protection against dental erosion relative to the NaF/triclosan dentifrice
Original languageEnglish
JournalAmerican Journal of Dentistry
Publication statusPublished - 1 Jun 2019


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