TY - JOUR
T1 - The Even-Handed Approach: Strategies for the Deployment of Racemic Chiral Catalysts
AU - Evans, Louise A.
AU - Hodnett, Neil S.
AU - Lloyd-Jones, Guy C.
PY - 2012
Y1 - 2012
N2 - Asymmetric catalysis is predominantly associated with the use of enantiomerically pure chiral ligands and catalysts. Although racemic chiral catalysts have been employed quite extensively in polymerization, their utility in mainstream organic synthesis and catalyst development has arguably been rather overlooked. This Minireview collates various themes for the strategic application of racemic ligands and catalysts, ranging from the estimation of selectivity and determination of enantiomeric excess, through to control of regio- and stereochemical outcomes, and mechanistic studies. What emerges is a clear picture that, in isolation or in concert with enantiopure catalysts, the even-handed approach has much to offer.
AB - Asymmetric catalysis is predominantly associated with the use of enantiomerically pure chiral ligands and catalysts. Although racemic chiral catalysts have been employed quite extensively in polymerization, their utility in mainstream organic synthesis and catalyst development has arguably been rather overlooked. This Minireview collates various themes for the strategic application of racemic ligands and catalysts, ranging from the estimation of selectivity and determination of enantiomeric excess, through to control of regio- and stereochemical outcomes, and mechanistic studies. What emerges is a clear picture that, in isolation or in concert with enantiopure catalysts, the even-handed approach has much to offer.
U2 - 10.1002/anie.201106836
DO - 10.1002/anie.201106836
M3 - Review article (Academic Journal)
C2 - 22241535
SN - 1433-7851
VL - 51
SP - 1526
EP - 1533
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 7
ER -