The expanding role of WEE1

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5 Citations (Scopus)

Abstract

Upon DNA damage, complex transduction cascades are unleashed to locate, recognise and repair affected lesions. The process triggers a pause in the cell cycle until the damage is resolved. Even under physiologic conditions, this deliberate interruption of cell division is essential to ensure orderly DNA replication and chromosomal segregation. WEE1 is an established regulatory protein in this vast fidelity-monitoring machinery. Its involvement in the DNA damage response and cell cycle has been a subject of study for decades. Emerging studies have also implicated WEE1 directly and indirectly in other cellular functions, including chromatin remodelling and immune response. The expanding role of WEE1 in pathophysiology is matched by the keen surge of interest in developing WEE1-targeted therapeutic agents. This review summarises WEE1 involvement in the cell cycle checkpoints, epigenetic modification and immune signalling, as well as the current state of WEE1 inhibitors in cancer therapeutics.

Original languageEnglish
Article number110310
JournalCellular Signalling
Volume94
Early online date16 Mar 2022
DOIs
Publication statusPublished - 1 Jun 2022

Bibliographical note

Funding Information:
The Koh Laboratory thanks the funding support from the University of Bristol , and the Bristol & Weston Hospitals Charity .

Publisher Copyright:
© 2022

Keywords

  • Antineoplastic Agents/pharmacology
  • Cell Cycle Proteins/metabolism
  • DNA Damage
  • DNA Replication
  • Protein-Tyrosine Kinases/metabolism

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