Abstract
BACKGROUND: Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early.
METHODS: During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system.
RESULTS: Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL).
CONCLUSIONS: Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.
Original language | English |
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Pages (from-to) | 1331-1336 |
Number of pages | 6 |
Journal | Anesthesia and Analgesia |
Volume | 120 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2015 |
Keywords
- Administration, Inhalation
- Ambulances
- Anesthesia, Closed-Circuit
- Asphyxia Neonatorum
- Emergency Medical Services
- England
- Equipment Design
- Feasibility Studies
- Humans
- Hypothermia, Induced
- Infant, Newborn
- Point-of-Care Systems
- Prospective Studies
- Respiration, Artificial
- Time Factors
- Treatment Outcome
- Ventilators, Mechanical
- Xenon
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Dr Hannah Gill
- School of Physiology, Pharmacology & Neuroscience - Honorary Senior Lecturer
Person: Honorary and Visiting Academic