The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval

John Dingley; Xun Liu; Hannah Gill; Elisa Smit; Hemmen Sabir; James Tooley; Ela Chakkarapani; David Windsor; Marianne Thoresen

doi:10.1213/ANE.0000000000000693

The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval

John Dingley, Xun Liu, Hannah Gill, Elisa Smit, Hemmen Sabir, James Tooley, Ela Chakkarapani, David Windsor, Marianne Thoresen

Research output: Contribution to journal › Article (Academic Journal) › peer-review

13 Citations (Scopus)

Abstract

BACKGROUND: Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early.

METHODS: During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system.

RESULTS: Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL).

CONCLUSIONS: Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.

Original language	English
Pages (from-to)	1331-1336
Number of pages	6
Journal	Anesthesia and Analgesia
Volume	120
Issue number	6
DOIs	https://doi.org/10.1213/ANE.0000000000000693
Publication status	Published - Jun 2015

Keywords

Administration, Inhalation
Ambulances
Anesthesia, Closed-Circuit
Asphyxia Neonatorum
Emergency Medical Services
England
Equipment Design
Feasibility Studies
Humans
Hypothermia, Induced
Infant, Newborn
Point-of-Care Systems
Prospective Studies
Respiration, Artificial
Time Factors
Treatment Outcome
Ventilators, Mechanical
Xenon

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10.1213/ANE.0000000000000693

Dr Hannah Gill
- Hannah.Gillbristol.acuk
- School of Physiology, Pharmacology & Neuroscience - Honorary Senior Lecturer
Person: Honorary and Visiting Academic

Cite this

Dingley, John ; Liu, Xun ; Gill, Hannah ; Smit, Elisa ; Sabir, Hemmen ; Tooley, James ; Chakkarapani, Ela ; Windsor, David ; Thoresen, Marianne. / The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval. In: Anesthesia and Analgesia. 2015 ; Vol. 120, No. 6. pp. 1331-1336.

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title = "The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval",

abstract = "BACKGROUND: Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early.METHODS: During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system.RESULTS: Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL).CONCLUSIONS: Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.",

keywords = "Administration, Inhalation, Ambulances, Anesthesia, Closed-Circuit, Asphyxia Neonatorum, Emergency Medical Services, England, Equipment Design, Feasibility Studies, Humans, Hypothermia, Induced, Infant, Newborn, Point-of-Care Systems, Prospective Studies, Respiration, Artificial, Time Factors, Treatment Outcome, Ventilators, Mechanical, Xenon",

author = "John Dingley and Xun Liu and Hannah Gill and Elisa Smit and Hemmen Sabir and James Tooley and Ela Chakkarapani and David Windsor and Marianne Thoresen",

year = "2015",

month = jun,

doi = "10.1213/ANE.0000000000000693",

language = "English",

volume = "120",

pages = "1331--1336",

journal = "Anesthesia and Analgesia",

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Dingley, J, Liu, X, Gill, H, Smit, E, Sabir, H, Tooley, J, Chakkarapani, E, Windsor, D & Thoresen, M 2015, 'The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval', Anesthesia and Analgesia, vol. 120, no. 6, pp. 1331-1336. https://doi.org/10.1213/ANE.0000000000000693

The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval. / Dingley, John; Liu, Xun; Gill, Hannah; Smit, Elisa; Sabir, Hemmen; Tooley, James; Chakkarapani, Ela; Windsor, David; Thoresen, Marianne.

In: Anesthesia and Analgesia, Vol. 120, No. 6, 06.2015, p. 1331-1336.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval

AU - Dingley, John

AU - Liu, Xun

AU - Gill, Hannah

AU - Smit, Elisa

AU - Sabir, Hemmen

AU - Tooley, James

AU - Chakkarapani, Ela

AU - Windsor, David

AU - Thoresen, Marianne

PY - 2015/6

Y1 - 2015/6

N2 - BACKGROUND: Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early.METHODS: During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system.RESULTS: Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL).CONCLUSIONS: Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.

AB - BACKGROUND: Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early.METHODS: During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system.RESULTS: Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL).CONCLUSIONS: Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.

KW - Administration, Inhalation

KW - Ambulances

KW - Anesthesia, Closed-Circuit

KW - Asphyxia Neonatorum

KW - Emergency Medical Services

KW - England

KW - Equipment Design

KW - Feasibility Studies

KW - Humans

KW - Hypothermia, Induced

KW - Infant, Newborn

KW - Point-of-Care Systems

KW - Prospective Studies

KW - Respiration, Artificial

KW - Time Factors

KW - Treatment Outcome

KW - Ventilators, Mechanical

KW - Xenon

U2 - 10.1213/ANE.0000000000000693

DO - 10.1213/ANE.0000000000000693

M3 - Article (Academic Journal)

C2 - 25794112

VL - 120

SP - 1331

EP - 1336

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 6

ER -

The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval

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Keywords

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Dr Hannah Gill

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