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The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1331-1336
Number of pages6
JournalAnesthesia and Analgesia
Issue number6
DatePublished - Jun 2015


BACKGROUND: Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early.

METHODS: During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system.

RESULTS: Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL).

CONCLUSIONS: Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.

    Research areas

  • Administration, Inhalation, Ambulances, Anesthesia, Closed-Circuit, Asphyxia Neonatorum, Emergency Medical Services, England, Equipment Design, Feasibility Studies, Humans, Hypothermia, Induced, Infant, Newborn, Point-of-Care Systems, Prospective Studies, Respiration, Artificial, Time Factors, Treatment Outcome, Ventilators, Mechanical, Xenon


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