The first complete papillomavirus genome characterized from a marsupial host: A novel isolate from Bettongia penicillata

Mark D. Bennett, Andrea Reiss, Hans Stevens, Elisabeth Heylen, Marc Van Ranst, Adrian Wayne, Michael Slaven, Jennifer N. Mills, Kristin S. Warren, Amanda J. O'Hara, P. K. Nicholls

Research output: Contribution to journalArticle (Academic Journal)peer-review

19 Citations (Scopus)

Abstract

The first fully sequenced papillomavirus (PV) of marsupials, tentatively named Bettongia penicillata papillomavirus type 1 (BpPV1), was detected in papillomas from a woylie (Bettongia penicillata ogilbyi). The circular, double-stranded DNA genome contains 7,737 bp and encodes 7 open reading frames (ORFs), E6, E7, E1, E2, E4, L2, and L1, in typical PV conformation. BpPV1 is a close-to-root PV with L1 and L2 ORFs most similar to European hedgehog PV and bandicoot papillomatosis carcinomatosis virus types 1 and 2 (BPCV1 and -2). It appears that the BPCVs arose by recombination between an ancient PV and an ancient polyomavirus more than 10 million years ago.

Original languageEnglish
Pages (from-to)5448-5453
Number of pages6
JournalJournal of Virology
Volume84
Issue number10
DOIs
Publication statusPublished - May 2010

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