The genetic architecture of psychophysiological phenotypes

Marcus R Munafò, Jonathan Flint

Research output: Contribution to journalArticle (Academic Journal)peer-review

21 Citations (Scopus)


It is now clear that almost all complex traits have a highly polygenic component; that is, their genetic basis consists of relatively frequent risk alleles at a very large number of loci, each making a small contribution to variation, or disease susceptibility. This general conclusion appears to hold for intermediate phenotypes. Therefore, we should not expect these phenotypes to be associated with substantially larger effect sizes than conventional phenotypes. Instead, their usefulness is likely to lie in understanding the mechanism underpinning associations identified via genome-wide association studies of conventional phenotypes.

Original languageEnglish
Pages (from-to)1331-2
Number of pages2
Issue number12
Publication statusPublished - Dec 2014

Bibliographical note

© 2014 The Authors. Psychophysiology published by Wiley Periodicals, Inc. on behalf of Society for Psychophysiological Research.

Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol


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