The genetic epidemiology of obesity: a case study

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)


Obesity (OMIM #601665) is a disease where excessive stores of body fat impact negatively on health. The first law of thermodynamics dictates that energy cannot be created or destroyed so if energy is taken into the body, but not transformed to ATP for metabolic work or dissipated as heat, it will be stored as fat. Therefore, the ultimate cause of obesity is a long-term positive energy imbalance [energy intake (EI) exceeds energy expenditure (EE)]. Despite this simple explanation, there is no single reason why EI may exceed EE meaning that the proximate causes of obesity are multi-factorial in origin involving a complex interplay of genetic, behavioural, and environmental influences on metabolism, diet, and activity.
Original languageEnglish
Pages (from-to)227-37
Number of pages11
JournalMethods in Molecular Biology
Publication statusPublished - 2011

Fingerprint Dive into the research topics of 'The genetic epidemiology of obesity: a case study'. Together they form a unique fingerprint.

Cite this