TY - JOUR
T1 - The genomes of four tapeworm species reveal adaptations to parasitism
AU - The Taenia solium Genome Consortium
AU - Tsai, Isheng J.
AU - Zarowiecki, Magdalena
AU - Holroyd, Nancy
AU - Garciarrubio, Alejandro
AU - Sanchez-Flores, Alejandro
AU - Brooks, Karen L.
AU - Tracey, Alan
AU - Bobes, Raúl J.
AU - Fragoso, Gladis
AU - Sciutto, Edda
AU - Aslett, Martin
AU - Beasley, Helen
AU - Bennett, Hayley M.
AU - Cai, Jianping
AU - Camicia, Federico
AU - Clark, Richard
AU - Cucher, Marcela
AU - De Silva, Nishadi
AU - Day, Tim A.
AU - Deplazes, Peter
AU - Estrada, Karel
AU - Fernández, Cecilia
AU - Holland, Peter W.H.
AU - Hou, Junling
AU - Hu, Songnian
AU - Huckvale, Thomas
AU - Hung, Stacy S.
AU - Kamenetzky, Laura
AU - Keane, Jacqueline A.
AU - Kiss, Ferenc
AU - Koziol, Uriel
AU - Lambert, Olivia
AU - Liu, Kan
AU - Luo, Xuenong
AU - Luo, Yingfeng
AU - MacChiaroli, Natalia
AU - Nichol, Sarah
AU - Paps, Jordi
AU - Parkinson, John
AU - Pouchkina-Stantcheva, Natasha
AU - Riddiford, Nick
AU - Rosenzvit, Mara
AU - Salinas, Gustavo
AU - Wasmuth, James D.
AU - Zamanian, Mostafa
AU - Zheng, Yadong
AU - Cai, Xuepeng
AU - Soberón, Xavier
AU - Olson, Peter D.
AU - Laclette, Juan P.
PY - 2013/4/4
Y1 - 2013/4/4
N2 - Tapeworms (Cestoda) cause neglected diseases that can be fatal and are difficult to treat, owing to inefficient drugs. Here we present an analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium and the laboratory model Hymenolepis microstoma as examples. The 115-to 141-megabase genomes offer insights into the evolution of parasitism. Synteny is maintained with distantly related blood flukes but we find extreme losses of genes and pathways that are ubiquitous in other animals, including 34 homeobox families and several determinants of stem cell fate. Tapeworms have specialized detoxification pathways, metabolism that is finely tuned to rely on nutrients scavenged from their hosts, and species-specific expansions of non-canonical heat shock proteins and families of known antigens. We identify new potential drug targets, including some on which existing pharmaceuticals may act. The genomes provide a rich resource to underpin the development of urgently needed treatments and control.
AB - Tapeworms (Cestoda) cause neglected diseases that can be fatal and are difficult to treat, owing to inefficient drugs. Here we present an analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium and the laboratory model Hymenolepis microstoma as examples. The 115-to 141-megabase genomes offer insights into the evolution of parasitism. Synteny is maintained with distantly related blood flukes but we find extreme losses of genes and pathways that are ubiquitous in other animals, including 34 homeobox families and several determinants of stem cell fate. Tapeworms have specialized detoxification pathways, metabolism that is finely tuned to rely on nutrients scavenged from their hosts, and species-specific expansions of non-canonical heat shock proteins and families of known antigens. We identify new potential drug targets, including some on which existing pharmaceuticals may act. The genomes provide a rich resource to underpin the development of urgently needed treatments and control.
UR - http://www.scopus.com/inward/record.url?scp=84875909456&partnerID=8YFLogxK
U2 - 10.1038/nature12031
DO - 10.1038/nature12031
M3 - Article (Academic Journal)
C2 - 23485966
SN - 0028-0836
VL - 496
SP - 57
EP - 63
JO - Nature
JF - Nature
IS - 7443
ER -