The global meningococcal initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection

Ray Borrow, Pedro Alarcon, Josefina Carlos, Dominique Caugant, Hannah Christensen, Roberto Debbag, Philippe De Wals, Gabriela Echániz-Aviles,, Jamie Findlow, Chris Head, Daphne Holt, Hajime Kamiya, Samir Saha, Sergey Sidorenko, Muhamed-Kheir Taha, Caroline Trotter, Julio Vázquez Moreno, Anne Von Gottberg

Research output: Contribution to journalArticle (Academic Journal)

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Abstract

Introduction: The 2015 Global Meningococcal Initiative (GMI) meeting discussed the global importance of meningococcal disease (MD) and its continually changing epidemiology.

Areas covered: Although recent vaccination programs have been successful in reducing incidence in many countries (e.g. Neisseria meningitidis serogroup [Men]C in Brazil, MenA in the African meningitis belt), new clones have emerged, causing outbreaks (e.g. MenW in South America, MenC in Nigeria and Niger). The importance of herd protection was highlighted, emphasizing the need for high vaccination uptake among those with the highest carriage rates, as was the need for boosters to maintain individual and herd protection following decline of immune response after primary immunization.

Expert commentary: The GMI Global Recommendations for Meningococcal Disease were updated to include a recommendation to enable access to whole-genome sequencing as for surveillance, guidance on strain typing to guide use of subcapsular vaccines, and recognition of the importance of advocacy and awareness campaigns.
Original languageEnglish
Pages (from-to)313-328
Number of pages15
JournalExpert Review of Vaccines
Volume16
Issue number4
Early online date8 Nov 2016
DOIs
Publication statusE-pub ahead of print - 8 Nov 2016

Bibliographical note

Bristol author, Hannah Christensen was on maternity leave when this paper was accepted. Her Cambridge co-author added the AAM to repository within 3 months of acceptance.

Keywords

  • Epidemiology, Global Meningococcal Initiative, meningococcal disease, MenW, Neisseria meningitidis, outbreaks, prevention, serogroups, surveillance, vaccination

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  • Cite this

    Borrow, R., Alarcon, P., Carlos, J., Caugant, D., Christensen, H., Debbag, R., De Wals, P., Echániz-Aviles, G., Findlow, J., Head, C., Holt, D., Kamiya, H., Saha, S., Sidorenko, S., Taha, M-K., Trotter, C., Vázquez Moreno, J., & Von Gottberg, A. (2016). The global meningococcal initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection. Expert Review of Vaccines, 16(4), 313-328. https://doi.org/10.1080/14760584.2017.1258308