The global meningococcal initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection

Ray Borrow; Pedro Alarcon; Josefina Carlos; Dominique Caugant; Hannah Christensen; Roberto Debbag; Philippe De Wals; Gabriela Echániz-Aviles,; Jamie Findlow; Chris Head; Daphne Holt; Hajime Kamiya; Samir Saha; Sergey Sidorenko; Muhamed-Kheir Taha; Caroline Trotter; Julio Vázquez Moreno; Anne Von Gottberg

doi:10.1080/14760584.2017.1258308

The global meningococcal initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection

Ray Borrow
, Pedro Alarcon
, Josefina Carlos
, Dominique Caugant
, Hannah Christensen
, Roberto Debbag
, Philippe De Wals
, Gabriela Echániz-Aviles,
, Jamie Findlow
, Chris Head
, Daphne Holt
, Hajime Kamiya
, Samir Saha
, Sergey Sidorenko
, Muhamed-Kheir Taha
, Caroline Trotter
, Julio Vázquez Moreno
, Anne Von Gottberg

Research output: Contribution to journal › Article (Academic Journal) › peer-review

222 Citations (Scopus)

467 Downloads (Pure)

Abstract

Introduction: The 2015 Global Meningococcal Initiative (GMI) meeting discussed the global importance of meningococcal disease (MD) and its continually changing epidemiology.

Areas covered: Although recent vaccination programs have been successful in reducing incidence in many countries (e.g. Neisseria meningitidis serogroup [Men]C in Brazil, MenA in the African meningitis belt), new clones have emerged, causing outbreaks (e.g. MenW in South America, MenC in Nigeria and Niger). The importance of herd protection was highlighted, emphasizing the need for high vaccination uptake among those with the highest carriage rates, as was the need for boosters to maintain individual and herd protection following decline of immune response after primary immunization.

Expert commentary: The GMI Global Recommendations for Meningococcal Disease were updated to include a recommendation to enable access to whole-genome sequencing as for surveillance, guidance on strain typing to guide use of subcapsular vaccines, and recognition of the importance of advocacy and awareness campaigns.

Original language	English
Pages (from-to)	313-328
Number of pages	15
Journal	Expert Review of Vaccines
Volume	16
Issue number	4
Early online date	8 Nov 2016
DOIs	https://doi.org/10.1080/14760584.2017.1258308
Publication status	E-pub ahead of print - 8 Nov 2016

Bibliographical note

Bristol author, Hannah Christensen was on maternity leave when this paper was accepted. Her Cambridge co-author added the AAM to repository within 3 months of acceptance.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Epidemiology, Global Meningococcal Initiative, meningococcal disease, MenW, Neisseria meningitidis, outbreaks, prevention, serogroups, surveillance, vaccination

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10.1080/14760584.2017.1258308

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https://www.repository.cam.ac.uk/handle/1810/262195Licence: CC BY-NC-ND

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Borrow, R., Alarcon, P., Carlos, J., Caugant, D., Christensen, H., Debbag, R., De Wals, P., Echániz-Aviles, G., Findlow, J., Head, C., Holt, D., Kamiya, H., Saha, S., Sidorenko, S., Taha, M.-K., Trotter, C., Vázquez Moreno, J., & Von Gottberg, A. (2016). The global meningococcal initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection. Expert Review of Vaccines, 16(4), 313-328. Advance online publication. https://doi.org/10.1080/14760584.2017.1258308

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title = "The global meningococcal initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection",

abstract = "Introduction: The 2015 Global Meningococcal Initiative (GMI) meeting discussed the global importance of meningococcal disease (MD) and its continually changing epidemiology. Areas covered: Although recent vaccination programs have been successful in reducing incidence in many countries (e.g. Neisseria meningitidis serogroup [Men]C in Brazil, MenA in the African meningitis belt), new clones have emerged, causing outbreaks (e.g. MenW in South America, MenC in Nigeria and Niger). The importance of herd protection was highlighted, emphasizing the need for high vaccination uptake among those with the highest carriage rates, as was the need for boosters to maintain individual and herd protection following decline of immune response after primary immunization. Expert commentary: The GMI Global Recommendations for Meningococcal Disease were updated to include a recommendation to enable access to whole-genome sequencing as for surveillance, guidance on strain typing to guide use of subcapsular vaccines, and recognition of the importance of advocacy and awareness campaigns.",

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note = "Bristol author, Hannah Christensen was on maternity leave when this paper was accepted. Her Cambridge co-author added the AAM to repository within 3 months of acceptance.",

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Borrow, R, Alarcon, P, Carlos, J, Caugant, D, Christensen, H, Debbag, R, De Wals, P, Echániz-Aviles, G, Findlow, J, Head, C, Holt, D, Kamiya, H, Saha, S, Sidorenko, S, Taha, M-K, Trotter, C, Vázquez Moreno, J & Von Gottberg, A 2016, 'The global meningococcal initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection', Expert Review of Vaccines, vol. 16, no. 4, pp. 313-328. https://doi.org/10.1080/14760584.2017.1258308

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AU - Borrow, Ray

AU - Alarcon, Pedro

AU - Carlos, Josefina

AU - Caugant, Dominique

AU - Christensen, Hannah

AU - Debbag, Roberto

AU - De Wals, Philippe

AU - Echániz-Aviles,, Gabriela

AU - Findlow, Jamie

AU - Head, Chris

AU - Holt, Daphne

AU - Kamiya, Hajime

AU - Saha, Samir

AU - Sidorenko, Sergey

AU - Taha, Muhamed-Kheir

AU - Trotter, Caroline

AU - Vázquez Moreno, Julio

AU - Von Gottberg, Anne

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N2 - Introduction: The 2015 Global Meningococcal Initiative (GMI) meeting discussed the global importance of meningococcal disease (MD) and its continually changing epidemiology. Areas covered: Although recent vaccination programs have been successful in reducing incidence in many countries (e.g. Neisseria meningitidis serogroup [Men]C in Brazil, MenA in the African meningitis belt), new clones have emerged, causing outbreaks (e.g. MenW in South America, MenC in Nigeria and Niger). The importance of herd protection was highlighted, emphasizing the need for high vaccination uptake among those with the highest carriage rates, as was the need for boosters to maintain individual and herd protection following decline of immune response after primary immunization. Expert commentary: The GMI Global Recommendations for Meningococcal Disease were updated to include a recommendation to enable access to whole-genome sequencing as for surveillance, guidance on strain typing to guide use of subcapsular vaccines, and recognition of the importance of advocacy and awareness campaigns.

AB - Introduction: The 2015 Global Meningococcal Initiative (GMI) meeting discussed the global importance of meningococcal disease (MD) and its continually changing epidemiology. Areas covered: Although recent vaccination programs have been successful in reducing incidence in many countries (e.g. Neisseria meningitidis serogroup [Men]C in Brazil, MenA in the African meningitis belt), new clones have emerged, causing outbreaks (e.g. MenW in South America, MenC in Nigeria and Niger). The importance of herd protection was highlighted, emphasizing the need for high vaccination uptake among those with the highest carriage rates, as was the need for boosters to maintain individual and herd protection following decline of immune response after primary immunization. Expert commentary: The GMI Global Recommendations for Meningococcal Disease were updated to include a recommendation to enable access to whole-genome sequencing as for surveillance, guidance on strain typing to guide use of subcapsular vaccines, and recognition of the importance of advocacy and awareness campaigns.

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DO - 10.1080/14760584.2017.1258308

M3 - Article (Academic Journal)

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SN - 1476-0584

VL - 16

SP - 313

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JO - Expert Review of Vaccines

JF - Expert Review of Vaccines

IS - 4

ER -

The global meningococcal initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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