The glomerular endothelium emerges as a key player in diabetic nephropathy

Research output: Contribution to journalArticle (Academic Journal)peer-review

38 Citations (Scopus)

Abstract

The effects of diabetes on glomerular structure and particularly that of the glomerular capillary wall have been extensively documented. By correlation with clinical measurements, Weil and colleagues provide important insights into the functional significance of glomerular structural changes in type 2 diabetes. Podocyte detachment correlates with albumin-to-creatinine ratio, but less strongly than does loss of endothelial fenestrations, which also correlates with reduced glomerular filtration rate. The role of the glomerular endothelium in diabetic nephropathy demands further scrutiny.

Original languageEnglish
Pages (from-to)949-51
Number of pages3
JournalKidney International
Volume82
Issue number9
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Diabetes Mellitus, Type 2
  • Diabetic Nephropathies
  • Female
  • Humans
  • Kidney Glomerulus
  • Losartan
  • Male
  • Podocytes

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