TY - JOUR
T1 - The hallmarks of cancer are also the hallmarks of wound healing
AU - Maccarthy-Morrogh, Lucy J
AU - Martin, Paul B
PY - 2020/9/8
Y1 - 2020/9/8
N2 - The Hanahan and Weinberg “hallmarks of cancer” papers provide a useful structure for considering the various mechanisms driving cancer progression, and the same might be useful for wound healing. In this Review, we highlight how tissue repair and cancer share cellular and molecular processes that are regulated in a wound but misregulated in cancer. From sustained proliferative signaling and the activation of invasion and angiogenesis to the promoting role of inflammation, there are many obvious parallels through which one process can inform the other. For some hallmarks, the parallels are more obscure. We propose some new prospective hallmarks that might apply to both cancer and wound healing and discuss how wounding, as in biopsy and surgery, might positively or negatively influence cancer in the clinic.
AB - The Hanahan and Weinberg “hallmarks of cancer” papers provide a useful structure for considering the various mechanisms driving cancer progression, and the same might be useful for wound healing. In this Review, we highlight how tissue repair and cancer share cellular and molecular processes that are regulated in a wound but misregulated in cancer. From sustained proliferative signaling and the activation of invasion and angiogenesis to the promoting role of inflammation, there are many obvious parallels through which one process can inform the other. For some hallmarks, the parallels are more obscure. We propose some new prospective hallmarks that might apply to both cancer and wound healing and discuss how wounding, as in biopsy and surgery, might positively or negatively influence cancer in the clinic.
U2 - 10.1126/scisignal.aay8690
DO - 10.1126/scisignal.aay8690
M3 - Book/Film/Article review (Academic Journal)
C2 - 32900881
VL - 13
JO - Science Signaling
JF - Science Signaling
SN - 1945-0877
IS - 648
M1 - eaay8690
ER -