The hallmarks of cancer are also the hallmarks of wound healing

Lucy J Maccarthy-Morrogh; Paul B Martin

doi:10.1126/scisignal.aay8690

The hallmarks of cancer are also the hallmarks of wound healing

Lucy J Maccarthy-Morrogh^*, Paul B Martin^*

^*Corresponding author for this work

Research output: Contribution to journal › Book/Film/Article review (Academic Journal) › peer-review

127 Citations (Scopus)

641 Downloads (Pure)

Abstract

The Hanahan and Weinberg “hallmarks of cancer” papers provide a useful structure for considering the various mechanisms driving cancer progression, and the same might be useful for wound healing. In this Review, we highlight how tissue repair and cancer share cellular and molecular processes that are regulated in a wound but misregulated in cancer. From sustained proliferative signaling and the activation of invasion and angiogenesis to the promoting role of inflammation, there are many obvious parallels through which one process can inform the other. For some hallmarks, the parallels are more obscure. We propose some new prospective hallmarks that might apply to both cancer and wound healing and discuss how wounding, as in biopsy and surgery, might positively or negatively influence cancer in the clinic.

Original language	English
Article number	eaay8690
Journal	Science Signaling
Volume	13
Issue number	648
DOIs	https://doi.org/10.1126/scisignal.aay8690
Publication status	Published - 8 Sept 2020

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SDG 3 Good Health and Well-being

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The hallmarks of cancer are also the hallmarks of wound healing

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