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The hippocampal engram maps experience but not place

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The hippocampal engram maps experience but not place. / Tanaka, Kazumasa; He, Hongshen; Tomar, Anupratap; Nisato, Kazue; Huang, Arthur; McHugh, Thomas J.

In: Science, Vol. 361, No. 6400, 27.07.2018, p. 392-397.

Research output: Contribution to journalArticle

Harvard

Tanaka, K, He, H, Tomar, A, Nisato, K, Huang, A & McHugh, TJ 2018, 'The hippocampal engram maps experience but not place', Science, vol. 361, no. 6400, pp. 392-397. https://doi.org/10.1126/science.aat5397

APA

Tanaka, K., He, H., Tomar, A., Nisato, K., Huang, A., & McHugh, T. J. (2018). The hippocampal engram maps experience but not place. Science, 361(6400), 392-397. https://doi.org/10.1126/science.aat5397

Vancouver

Tanaka K, He H, Tomar A, Nisato K, Huang A, McHugh TJ. The hippocampal engram maps experience but not place. Science. 2018 Jul 27;361(6400):392-397. https://doi.org/10.1126/science.aat5397

Author

Tanaka, Kazumasa ; He, Hongshen ; Tomar, Anupratap ; Nisato, Kazue ; Huang, Arthur ; McHugh, Thomas J. / The hippocampal engram maps experience but not place. In: Science. 2018 ; Vol. 361, No. 6400. pp. 392-397.

Bibtex

@article{b2d020a2685e472aac1f1a07c56527d5,
title = "The hippocampal engram maps experience but not place",
abstract = "Episodic memories are encoded by a sparse population of hippocampal neurons. In mice, optogenetic manipulation of this memory engram established that these neurons are indispensable and inducing for memory recall. However, little is known about their in vivo activity or precise role in memory. We found that during memory encoding, only a fraction of CA1 place cells function as engram neurons, distinguished by firing repetitive bursts paced at the theta frequency. During memory recall, these neurons remained highly context specific, yet demonstrated preferential remapping of their place fields. These data demonstrate a dissociation of precise spatial coding and contextual indexing by distinct hippocampal ensembles and suggest that the hippocampal engram serves as an index of memory content.",
keywords = "engrams, place cells, Hippocampus, memory Indexing",
author = "Kazumasa Tanaka and Hongshen He and Anupratap Tomar and Kazue Nisato and Arthur Huang and McHugh, {Thomas J}",
year = "2018",
month = "7",
day = "27",
doi = "10.1126/science.aat5397",
language = "English",
volume = "361",
pages = "392--397",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6400",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - The hippocampal engram maps experience but not place

AU - Tanaka, Kazumasa

AU - He, Hongshen

AU - Tomar, Anupratap

AU - Nisato, Kazue

AU - Huang, Arthur

AU - McHugh, Thomas J

PY - 2018/7/27

Y1 - 2018/7/27

N2 - Episodic memories are encoded by a sparse population of hippocampal neurons. In mice, optogenetic manipulation of this memory engram established that these neurons are indispensable and inducing for memory recall. However, little is known about their in vivo activity or precise role in memory. We found that during memory encoding, only a fraction of CA1 place cells function as engram neurons, distinguished by firing repetitive bursts paced at the theta frequency. During memory recall, these neurons remained highly context specific, yet demonstrated preferential remapping of their place fields. These data demonstrate a dissociation of precise spatial coding and contextual indexing by distinct hippocampal ensembles and suggest that the hippocampal engram serves as an index of memory content.

AB - Episodic memories are encoded by a sparse population of hippocampal neurons. In mice, optogenetic manipulation of this memory engram established that these neurons are indispensable and inducing for memory recall. However, little is known about their in vivo activity or precise role in memory. We found that during memory encoding, only a fraction of CA1 place cells function as engram neurons, distinguished by firing repetitive bursts paced at the theta frequency. During memory recall, these neurons remained highly context specific, yet demonstrated preferential remapping of their place fields. These data demonstrate a dissociation of precise spatial coding and contextual indexing by distinct hippocampal ensembles and suggest that the hippocampal engram serves as an index of memory content.

KW - engrams

KW - place cells

KW - Hippocampus

KW - memory Indexing

UR - http://www.scopus.com/inward/record.url?scp=85050948839&partnerID=8YFLogxK

U2 - 10.1126/science.aat5397

DO - 10.1126/science.aat5397

M3 - Article

VL - 361

SP - 392

EP - 397

JO - Science

JF - Science

SN - 0036-8075

IS - 6400

ER -