The impact of paternal alcohol, tobacco, caffeine use and physical activity on offspring mental health: a systematic review and meta-analysis

Kayleigh E Easey*, Gemma C Sharp

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Background
There is some evidence that paternal health behaviours during and around pregnancy could be associated with offspring health outcomes. However, the impact that paternal health behaviours during pregnancy can have on offspring mental health is understudied and remains unclear.

Methods
We conducted a systematic review and meta-analysis of articles in PubMed describing studies of potentially modifiable paternal health behaviours (tobacco smoking, alcohol consumption, caffeine consumption and physical activity) in the prenatal period in relation to offspring mental health. GRADE was used to measure risk of bias.

Results
Eight studies were included and categorized by paternal health behaviour and offspring mental health outcome investigated. The narrative synthesis provided evidence of association between paternal health behaviours around pregnancy and offspring mental health problems, with the strongest evidence shown for tobacco use. Grouped by analysis type, two separate meta-analyses showed evidence of paternal smoking during pregnancy being associated with greater odds of ADHD in offspring (OR 1.42, 95% CI 1.02–1.99; HR 1.28, 95% CI 1.19–1.39).

Conclusions
The small number of studies that have investigated paternal prenatal effects on offspring mental health, and the limited sample sizes of those studies, makes it challenging to draw firm conclusions. Although existing studies suggest that paternal tobacco smoking and alcohol consumption in the prenatal period are associated with poorer offspring mental health, (particularly hyperactivity/ADHD), further investigation of potential paternal effects is required, using methods that allow stronger inference to determine whether associations are causal.
Original languageEnglish
Article number214
Number of pages12
JournalReproductive Health
Volume18
DOIs
Publication statusPublished - 26 Oct 2021

Bibliographical note

Funding Information:
KEE and GCS are financially supported by an MRC New Investigator Research Grant awarded to Gemma Sharp (grant code MR/S009310/1). GCS is also financially supported by the European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL, NutriPROGRAM project, UK MRC MR/S036520/1).

Funding Information:
KEE and GCS work within the MRC Integrative Epidemiology Unit at the University of Bristol which is supported by the Medical Research Council (MRC) and the University of Bristol.

Publisher Copyright:
© 2021, The Author(s).

Keywords

  • Systematic review
  • Mental health
  • Tobacco
  • Alcohol
  • Caffeine
  • Physical activity
  • Fathers
  • Paternal
  • Pregnancy
  • Child health
  • Meta-analysis

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