The impact of radiotherapy on patient-reported outcomes of immediate implant-based breast reconstruction with and without mesh

Emma Sewart, Nicholas L Turner, Elizabeth Conroy, Ramsey Cutress, Joanna Skillman, Lisa Whisker, Steven Thrush, Nicola Barnes, Chris Holcombe, Shelley Potter*, the iBRA Steering Group and the Breast Reconstruction Research Collaborative

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Objective: To explore the impact of postmastectomy radiotherapy (PMRT) on patient-reported outcomes (PROs) of implant-based breast reconstruction (IBBR) performed with and without mesh. Summary background data: Post-mastectomy radiotherapy (PMRT) is increasingly given to improve breast cancer outcomes but can adversely impact complications following IBBR. Little, however, is known about the impact of PMRT on the PROs of IBBR, especially when mesh is used. Methods: The iBRA (implant Breast Reconstruction evAluation) prospective cohort study recruited consecutive women undergoing immediate IBBR from 81 UK breast and plastic surgical units. Demographic, operative, oncological and 3-month complication data were collected, and patients consented to receive validated PRO questionnaires at 18-months. The association between IBBR, PMRT and PROs were investigated using mixed-effects regression models adjusted for clinically-relevant confounders and including a random-effect to account for potential clustering by center Results: 1163 women consented to receive 18-month questionnaires of whom 730 (63%) completed it. Patients undergoing PMRT (214 patients) reported worse PROs in three BREAST-Q domains: satisfaction with breasts (-6.27 points, p=0.008,95% confidence interval (CI)[-10.91,-1.63]), satisfaction with outcome (-7.53 points, p=0.002,CI[-12.20,-2.85]) and physical well-being (-6.55 points, p<0.001, CI[-9.43,-3.67]). Overall satisfaction was worse in the PMRT group (OR 0.497, p=0.002, CI [0.32, 0.77]). These effects were not ameliorated by mesh use. Conclusions: PMRT may adversely affect PROs following IBBR irrespective of whether mesh is used. These findings should be discussed with all patients considering IBBR and when indications for PMRT are borderline to enable informed decision-making regarding oncological and reconstructive treatment options.
Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalAnnals of Surgery
Volume0
DOIs
Publication statusPublished - 9 Jul 2020

Structured keywords

  • Centre for Surgical Research
  • ConDuCT-II
  • Bristol Population Health Science Institute

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