The impact of study size on meta-analyses: examination of underpowered studies in Cochrane reviews

Rebecca M Turner; Sheila M Bird; Julian P T Higgins

doi:10.1371/journal.pone.0059202

The impact of study size on meta-analyses: examination of underpowered studies in Cochrane reviews

Rebecca M Turner, Sheila M Bird, Julian P T Higgins

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

294 Citations (Scopus)

Abstract

Most meta-analyses include data from one or more small studies that, individually, do not have power to detect an intervention effect. The relative influence of adequately powered and underpowered studies in published meta-analyses has not previously been explored. We examine the distribution of power available in studies within meta-analyses published in Cochrane reviews, and investigate the impact of underpowered studies on meta-analysis results.

Original language	English
Pages (from-to)	e59202
Journal	PLoS ONE
Volume	8
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0059202
Publication status	Published - 2013

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