The importance of overcoming the challenges in delivering the Proper Understanding of Recurrent Stress Urinary Incontinence Treatment (PURSUIT) study

Caroline Pope; Nikki  Cotterill; Marcus Drake; Beth M Fitzgerald; Tamsin  Greenwell; Swati  Jha; J. Athene Lane; Stephanie J MacNeill; Sangeetha Paramasivan; Wael Agur; Alison  White

doi:10.1016/j.cont.2022.100020

The importance of overcoming the challenges in delivering the Proper Understanding of Recurrent Stress Urinary Incontinence Treatment (PURSUIT) study

Caroline Pope, Nikki Cotterill, Marcus Drake^*, Beth M Fitzgerald, Tamsin Greenwell, Swati Jha, J. Athene Lane, Stephanie J MacNeill, Sangeetha Paramasivan, Wael Agur, Alison White

^*Corresponding author for this work

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Abstract

There is insufficient data to assess the effects of any of the different management strategies for recurrent or persistent stress urinary incontinence in women after failed interventional treatment. The evidence base lacks well-designed randomised trials with sufficient power to answer this hugely important issue. PURSUIT is the Proper Understanding of Recurrent Stress Urinary Incontinence Treatment study, assessing through randomisation whether endoscopic or surgical interventions achieve better cure and/or quality of life outcomes at 1 year, and will follow up to 3 years to see if responses are sustained. The manuscript provides an outline of the study, describes the challenges it has faced, and advocates the importance of ensuring its successful delivery.

Original language	English
Article number	100020
Journal	Continence UK Journal
Volume	1
Early online date	23 Mar 2022
DOIs	https://doi.org/10.1016/j.cont.2022.100020
Publication status	E-pub ahead of print - 23 Mar 2022

Keywords

Incontinence
Stress urinary incontinence
Surgery
Randomised controlled trial

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Pope, C., Cotterill, N., Drake, M., Fitzgerald, B. M., Greenwell, T., Jha, S., Lane, J. A., MacNeill, S. J., Paramasivan, S., Agur, W., & White , A. (2022). The importance of overcoming the challenges in delivering the Proper Understanding of Recurrent Stress Urinary Incontinence Treatment (PURSUIT) study. Continence UK Journal, 1, Article 100020. Advance online publication. https://doi.org/10.1016/j.cont.2022.100020

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abstract = "There is insufficient data to assess the effects of any of the different management strategies for recurrent or persistent stress urinary incontinence in women after failed interventional treatment. The evidence base lacks well-designed randomised trials with sufficient power to answer this hugely important issue. PURSUIT is the Proper Understanding of Recurrent Stress Urinary Incontinence Treatment study, assessing through randomisation whether endoscopic or surgical interventions achieve better cure and/or quality of life outcomes at 1 year, and will follow up to 3 years to see if responses are sustained. The manuscript provides an outline of the study, describes the challenges it has faced, and advocates the importance of ensuring its successful delivery.",

keywords = "Incontinence, Stress urinary incontinence, Surgery, Randomised controlled trial",

author = "Caroline Pope and Nikki Cotterill and Marcus Drake and Fitzgerald, {Beth M} and Tamsin Greenwell and Swati Jha and Lane, {J. Athene} and MacNeill, {Stephanie J} and Sangeetha Paramasivan and Wael Agur and Alison White",

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Pope, C, Cotterill, N, Drake, M, Fitzgerald, BM, Greenwell, T, Jha, S, Lane, JA , MacNeill, SJ , Paramasivan, S, Agur, W & White , A 2022, 'The importance of overcoming the challenges in delivering the Proper Understanding of Recurrent Stress Urinary Incontinence Treatment (PURSUIT) study', Continence UK Journal, vol. 1, 100020. https://doi.org/10.1016/j.cont.2022.100020

TY - JOUR

T1 - The importance of overcoming the challenges in delivering the Proper Understanding of Recurrent Stress Urinary Incontinence Treatment (PURSUIT) study

AU - Pope, Caroline

AU - Cotterill, Nikki

AU - Drake, Marcus

AU - Fitzgerald, Beth M

AU - Greenwell, Tamsin

AU - Jha, Swati

AU - Lane, J. Athene

AU - MacNeill, Stephanie J

AU - Paramasivan, Sangeetha

AU - Agur, Wael

AU - White , Alison

PY - 2022/3/23

Y1 - 2022/3/23

N2 - There is insufficient data to assess the effects of any of the different management strategies for recurrent or persistent stress urinary incontinence in women after failed interventional treatment. The evidence base lacks well-designed randomised trials with sufficient power to answer this hugely important issue. PURSUIT is the Proper Understanding of Recurrent Stress Urinary Incontinence Treatment study, assessing through randomisation whether endoscopic or surgical interventions achieve better cure and/or quality of life outcomes at 1 year, and will follow up to 3 years to see if responses are sustained. The manuscript provides an outline of the study, describes the challenges it has faced, and advocates the importance of ensuring its successful delivery.

AB - There is insufficient data to assess the effects of any of the different management strategies for recurrent or persistent stress urinary incontinence in women after failed interventional treatment. The evidence base lacks well-designed randomised trials with sufficient power to answer this hugely important issue. PURSUIT is the Proper Understanding of Recurrent Stress Urinary Incontinence Treatment study, assessing through randomisation whether endoscopic or surgical interventions achieve better cure and/or quality of life outcomes at 1 year, and will follow up to 3 years to see if responses are sustained. The manuscript provides an outline of the study, describes the challenges it has faced, and advocates the importance of ensuring its successful delivery.

KW - Incontinence

KW - Stress urinary incontinence

KW - Surgery

KW - Randomised controlled trial

U2 - 10.1016/j.cont.2022.100020

DO - 10.1016/j.cont.2022.100020

M3 - Article (Academic Journal)

VL - 1

JO - Continence UK Journal

JF - Continence UK Journal

M1 - 100020

ER -

The importance of overcoming the challenges in delivering the Proper Understanding of Recurrent Stress Urinary Incontinence Treatment (PURSUIT) study

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