The influence of bacterial vaginosis on in-vitro fertilization and embryo implantation during assisted reproduction treatment

JM Jenkins, MGR Hull, SD Keay, NH Liversedge, PJ Horner

    Research output: Contribution to journalArticle (Academic Journal)peer-review

    44 Citations (Scopus)

    Abstract

    There is growing evidence that the pathogenic effects of bacterial vaginosis may not be confined to the lower genital tract. Possible associations with infertility and effects on fertilization and implantation were studied in patients undergoing in-vitro fertilization (IVF) treatment. High vaginal swabs taken at the time of oocyte collection were assessed by Gram staining. The prevalence of bacterial vaginosis and of intermediate and normal flora in 301 patients was 25.6, 14.0 and 60.4% respectively. Bacterial vaginosis was more prevalent in patients with tubal (31.5%, n = 149) compared with non-tubal (19.7%, n = 152) infertility (odds ratio (OR) 1.87, CI 1.11–3.18, P = 0.02). Bacterial vaginosis did not have an adverse effect on fertilization rate. Further, no significant difference in implantation rates was seen when comparing bacterial vaginosis (15.8%, OR 1.03, CI 0.66–1.61) and intermediate flora (13.1%, OR 0.82, CI 0.45–1.52) with normal flora (15.5%). Though confidence intervals around the observations were relatively wide, the findings suggest that routine screening for bacterial vaginosis in the hope of improving the success of IVF treatment is not justified. The prevention of complications in pregnancy associated with bacterial vaginosis might be a more relevant indication for screening at the time of IVF treatment, in particular patients with tubal disease, if treatment were shown to be effective for that particular purpose. However, antibiotic treatment before IVF has been shown to be positively disadvantageous for IVF by encouraging other organisms.
    Translated title of the contributionThe influence of bacterial vaginosis on in-vitro fertilization and embryo implantation during assisted reproduction treatment
    Original languageEnglish
    Pages (from-to)2411-2415
    Number of pages5
    JournalHuman Reproduction
    Volume14
    Issue number9
    DOIs
    Publication statusPublished - 1 Sep 1999

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