The influence of harmaline on the movements of sodium ions in smooth muscle of the guinea pig ileum

M S Suleiman, R C Hider

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)

Abstract

The effect of changing the extracellular concentration of both Na+ and K+ on the longitudinal muscle of the guinea-pig ileum was studied in the presence and absence of harmaline. A decrease in extracellular Na+ concentration was found to produce a dose-dependent contractile response, which may suggest the existence of a Na-Ca exchange mechanism in this muscle. Harmaline (2 X 10(-4) M) was found to reversibly inhibit this contraction and was also found to selectively block the tonic component of high-K induced contradictions. In view of the fact that harmaline is a non-competitive inhibitor of Ca-induced contractions (Hider et al., Europ. J. Pharmacol., 71, 87, 1981), the action of harmaline was interpreted as being a specific inhibitor of the Na-Ca exchange mechanism, binding specifically to Na+ coordination sites.

Original languageEnglish
Pages (from-to)145-50
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume67
Issue number2
Publication statusPublished - Jul 1985

Keywords

  • Alkaloids
  • Animals
  • Biological Transport, Active
  • Calcium
  • Female
  • Guinea Pigs
  • Harmaline
  • Ileum
  • In Vitro Techniques
  • Muscle Contraction
  • Muscle, Smooth
  • Potassium
  • Sodium
  • Journal Article

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