The influence of the ligand chelate effect on iron-amine-catalysed Kumada cross-coupling

Robin Bedford, Peter B Brenner, David Elorriaga, Jeremy Harvey, Joshua Nunn

Research output: Contribution to journalArticle (Academic Journal)peer-review

26 Citations (Scopus)
465 Downloads (Pure)


The application of a variety of iron complexes with chelating amine ligands as pre-catalysts in the representative cross-coupling of 4-tolylmagnesium bromide with cyclohexyl bromide was investigated. The results from this study indicate the the performance of the pre-catalyst is inversely proportional to the strength of the chelate or macrocyclic effect of the amine ligand, as determined by the propensity of the ligand to be displaced from the iron centre by reaction with excess benzyl magnesium chloride. The findings from this study are consistent with a catalytic cycle wherein the chelating amine ligand is not coordinated to the iron centre during turnover.
Original languageEnglish
Pages (from-to)15811-15817
Number of pages7
JournalDalton Transactions
Issue number40
Early online date16 Jun 2016
Publication statusPublished - 28 Oct 2016


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